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Genetic heterogeneity in breast cancer: the road to personalized medicine?

More women die from breast cancer across the world today than from any other type of malignancy. The clinical course of breast cancer varies tremendously between patients. While some of this variability is explained by traditional clinico-pathological factors (including patient age, tumor stage, his...

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Detalles Bibliográficos
Autores principales: Baird, Richard D, Caldas, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689054/
https://www.ncbi.nlm.nih.gov/pubmed/23800221
http://dx.doi.org/10.1186/1741-7015-11-151
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author Baird, Richard D
Caldas, Carlos
author_facet Baird, Richard D
Caldas, Carlos
author_sort Baird, Richard D
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description More women die from breast cancer across the world today than from any other type of malignancy. The clinical course of breast cancer varies tremendously between patients. While some of this variability is explained by traditional clinico-pathological factors (including patient age, tumor stage, histological grade and estrogen receptor status), molecular profiling studies have defined breast cancer subtypes with distinct clinical outcomes. This mini-review considers recent studies which have used genomics technologies in an attempt to identify new biomarkers of prognosis and treatment response. These studies highlight the genetic heterogeneity that exists within breast cancers in space and time.
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spelling pubmed-36890542013-06-27 Genetic heterogeneity in breast cancer: the road to personalized medicine? Baird, Richard D Caldas, Carlos BMC Med Minireview More women die from breast cancer across the world today than from any other type of malignancy. The clinical course of breast cancer varies tremendously between patients. While some of this variability is explained by traditional clinico-pathological factors (including patient age, tumor stage, histological grade and estrogen receptor status), molecular profiling studies have defined breast cancer subtypes with distinct clinical outcomes. This mini-review considers recent studies which have used genomics technologies in an attempt to identify new biomarkers of prognosis and treatment response. These studies highlight the genetic heterogeneity that exists within breast cancers in space and time. BioMed Central 2013-06-18 /pmc/articles/PMC3689054/ /pubmed/23800221 http://dx.doi.org/10.1186/1741-7015-11-151 Text en Copyright © 2013 Baird and Caldas; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Minireview
Baird, Richard D
Caldas, Carlos
Genetic heterogeneity in breast cancer: the road to personalized medicine?
title Genetic heterogeneity in breast cancer: the road to personalized medicine?
title_full Genetic heterogeneity in breast cancer: the road to personalized medicine?
title_fullStr Genetic heterogeneity in breast cancer: the road to personalized medicine?
title_full_unstemmed Genetic heterogeneity in breast cancer: the road to personalized medicine?
title_short Genetic heterogeneity in breast cancer: the road to personalized medicine?
title_sort genetic heterogeneity in breast cancer: the road to personalized medicine?
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689054/
https://www.ncbi.nlm.nih.gov/pubmed/23800221
http://dx.doi.org/10.1186/1741-7015-11-151
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