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Genetic heterogeneity in breast cancer: the road to personalized medicine?
More women die from breast cancer across the world today than from any other type of malignancy. The clinical course of breast cancer varies tremendously between patients. While some of this variability is explained by traditional clinico-pathological factors (including patient age, tumor stage, his...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689054/ https://www.ncbi.nlm.nih.gov/pubmed/23800221 http://dx.doi.org/10.1186/1741-7015-11-151 |
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author | Baird, Richard D Caldas, Carlos |
author_facet | Baird, Richard D Caldas, Carlos |
author_sort | Baird, Richard D |
collection | PubMed |
description | More women die from breast cancer across the world today than from any other type of malignancy. The clinical course of breast cancer varies tremendously between patients. While some of this variability is explained by traditional clinico-pathological factors (including patient age, tumor stage, histological grade and estrogen receptor status), molecular profiling studies have defined breast cancer subtypes with distinct clinical outcomes. This mini-review considers recent studies which have used genomics technologies in an attempt to identify new biomarkers of prognosis and treatment response. These studies highlight the genetic heterogeneity that exists within breast cancers in space and time. |
format | Online Article Text |
id | pubmed-3689054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36890542013-06-27 Genetic heterogeneity in breast cancer: the road to personalized medicine? Baird, Richard D Caldas, Carlos BMC Med Minireview More women die from breast cancer across the world today than from any other type of malignancy. The clinical course of breast cancer varies tremendously between patients. While some of this variability is explained by traditional clinico-pathological factors (including patient age, tumor stage, histological grade and estrogen receptor status), molecular profiling studies have defined breast cancer subtypes with distinct clinical outcomes. This mini-review considers recent studies which have used genomics technologies in an attempt to identify new biomarkers of prognosis and treatment response. These studies highlight the genetic heterogeneity that exists within breast cancers in space and time. BioMed Central 2013-06-18 /pmc/articles/PMC3689054/ /pubmed/23800221 http://dx.doi.org/10.1186/1741-7015-11-151 Text en Copyright © 2013 Baird and Caldas; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Minireview Baird, Richard D Caldas, Carlos Genetic heterogeneity in breast cancer: the road to personalized medicine? |
title | Genetic heterogeneity in breast cancer: the road to personalized medicine? |
title_full | Genetic heterogeneity in breast cancer: the road to personalized medicine? |
title_fullStr | Genetic heterogeneity in breast cancer: the road to personalized medicine? |
title_full_unstemmed | Genetic heterogeneity in breast cancer: the road to personalized medicine? |
title_short | Genetic heterogeneity in breast cancer: the road to personalized medicine? |
title_sort | genetic heterogeneity in breast cancer: the road to personalized medicine? |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689054/ https://www.ncbi.nlm.nih.gov/pubmed/23800221 http://dx.doi.org/10.1186/1741-7015-11-151 |
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