Cargando…

BRCA1 in the DNA damage response and at telomeres

Mutations of the breast and ovarian cancer susceptibility gene 1 (BRCA1) account for about 40–45% of hereditary breast cancer cases. Moreover, a significant fraction of sporadic (non-hereditary) breast and ovarian cancers exhibit reduced or absent expression of the BRCA1 protein, suggesting an addit...

Descripción completa

Detalles Bibliográficos
Autor principal:	Rosen, Eliot M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689208/ https://www.ncbi.nlm.nih.gov/pubmed/23802008 http://dx.doi.org/10.3389/fgene.2013.00085

Ejemplares similares

Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair
por: Minami, Akari, et al.
Publicado: (2014)

BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage
por: Vohhodina, Jekaterina, et al.
Publicado: (2021)

Targeting BRCA and DNA Damage Repair Genes in GI Cancers: Pathophysiology and Clinical Perspectives
por: Zimmer, Kai, et al.
Publicado: (2021)

BRCA1, BRCA2 and their possible function in DNA damage response
por: Kote-Jarai, Z, et al.
Publicado: (1999)

DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
por: Rossiello, Francesca, et al.
Publicado: (2017)

The telomere protein tankyrase 1 regulates DNA damage responses at telomeres
por: Chang, Sandy
Publicado: (2010)

Corrigendum: DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
por: Rossiello, Francesca, et al.
Publicado: (2017)

Medulloblastoma and the DNA Damage Response
por: McSwain, Leon F., et al.
Publicado: (2022)

Molecular Trajectory of BRCA1 and BRCA2 Mutations
por: Hatano, Yuichiro, et al.
Publicado: (2020)

The Response to DNA Damage at Telomeric Repeats and Its Consequences for Telomere Function
por: Doksani, Ylli
Publicado: (2019)

TERRA, hnRNP A1, and DNA-PKcs Interactions at Human Telomeres
por: Le, Phuong N., et al.
Publicado: (2013)

The DNA damage response in mammalian oocytes
por: Carroll, John, et al.
Publicado: (2013)

Genomic landscape of advanced prostate cancer patients with BRCA1 versus BRCA2 mutations as detected by comprehensive genomic profiling of cell-free DNA
por: Swami, Umang, et al.
Publicado: (2022)

Landscape of germline BRCA1/BRCA2 variants in breast and ovarian cancer in Peru
por: Ferreyra, Yomali, et al.
Publicado: (2023)

Targeting the DNA Damage Response for Cancer Therapy by Inhibiting the Kinase Wee1
por: Bukhari, Amirali B., et al.
Publicado: (2022)

Genomic Profile and BRCA-1 Promoter Methylation Status in BRCA Mutated Ovarian Cancer: New Insights in Predictive Biomarkers of Olaparib Response
por: Franzese, Elisena, et al.
Publicado: (2019)

CRL Ubiquitin Ligases and DNA Damage Response
por: Li, Ju-Mei, et al.
Publicado: (2012)

Regulation of the DNA damage response by ubiquitin conjugation
por: Brinkmann, Kerstin, et al.
Publicado: (2015)

SNM1B/Apollo in the DNA damage response and telomere maintenance
por: Schmiester, Maren, et al.
Publicado: (2017)

Telomere Length Shows No Association with BRCA1 and BRCA2 Mutation Status
por: Killick, Emma, et al.
Publicado: (2014)

The Landscape and Therapeutic Targeting of BRCA1, BRCA2 and Other DNA Damage Response Genes in Pancreatic Cancer
por: Voutsadakis, Ioannis A., et al.
Publicado: (2023)

Targeting Ongoing DNA Damage in Multiple Myeloma: Effects of DNA Damage Response Inhibitors on Plasma Cell Survival
por: Herrero, Ana Belén, et al.
Publicado: (2017)

Alternative lengthening of telomeres: remodeling the telomere architecture
por: Conomos, Dimitri, et al.
Publicado: (2013)

The telomeric DNA damage response occurs in the absence of chromatin decompaction
por: Vancevska, Aleksandra, et al.
Publicado: (2017)

Chromatin modifications and the DNA damage response to ionizing radiation
por: Kumar, Rakesh, et al.
Publicado: (2013)

Editorial: Grappling with the Multifaceted World of the DNA Damage Response
por: Porro, Antonio
Publicado: (2016)

Editorial: Harnessing DNA Damage Response in Gynecologic Malignancies
por: Tse, Ka Yu, et al.
Publicado: (2022)

Role of BRCA Mutations in the Modulation of Response to Platinum Therapy
por: Mylavarapu, Sanghamitra, et al.
Publicado: (2018)

BRCA1 and BRCA2 Mutations Other Than the Founder Alleles Among Ashkenazi Jewish in the Population of Argentina
por: Solano, Angela R., et al.
Publicado: (2018)

Epigenetic Telomere Protection by Drosophila DNA Damage Response Pathways
por: Oikemus, Sarah R, et al.
Publicado: (2006)

Taming the tiger by the tail: modulation of DNA damage responses by telomeres
por: Lydall, David
Publicado: (2009)

Telomere length dynamics in response to DNA damage in malaria parasites
por: Reed, Jake, et al.
Publicado: (2021)

BRCA2 Haploinsufficiency in Telomere Maintenance
por: Gunnarsdottir, Soffía R., et al.
Publicado: (2021)

It takes two to tango: Ubiquitin and SUMO in the DNA damage response
por: Bologna, Serena, et al.
Publicado: (2013)

Histone Ubiquitination and Deubiquitination in Transcription, DNA Damage Response, and Cancer
por: Cao, Jian, et al.
Publicado: (2012)

Editorial: Exploiting DNA Damage Response in the Era of Precision Oncology
por: Zimmer, Yitzhak, et al.
Publicado: (2020)

Targeting the DNA Damage Response for the Treatment of High Risk Neuroblastoma
por: Southgate, Harriet E. D., et al.
Publicado: (2020)

Telomeres and Telomerase in the Radiation Response: Implications for Instability, Reprograming, and Carcinogenesis
por: Sishc, Brock J., et al.
Publicado: (2015)

HP1 promotes tumor suppressor BRCA1 functions during the DNA damage response
por: Lee, Young-Ho, et al.
Publicado: (2013)

AATF/Che-1—An RNA Binding Protein at the Nexus of DNA Damage Response and Ribosome Biogenesis
por: Kaiser, Rainer W. J., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_vfectk0btda3bsm4ont9cip540