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Proton-dependent inhibition of the cardiac sodium channel Na(v)1.5 by ranolazine

Ranolazine is clinically approved for treatment of angina pectoris and is a potential candidate for antiarrhythmic, antiepileptic, and analgesic applications. These therapeutic effects of ranolazine hinge on its ability to inhibit persistent or late Na(+) currents in a variety of voltage-gated sodiu...

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Detalles Bibliográficos
Autores principales:	Sokolov, S., Peters, C. H., Rajamani, S., Ruben, P. C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689222/ https://www.ncbi.nlm.nih.gov/pubmed/23801963 http://dx.doi.org/10.3389/fphar.2013.00078

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