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Substrate Channel Flexibility in Pseudomonas aeruginosa MurB Accommodates Two Distinct Substrates

Biosynthesis of UDP-N-acetylmuramic acid in bacteria is a committed step towards peptidoglycan production. In an NADPH- and FAD-dependent reaction, the UDP-N-acetylglucosamine-enolpyruvate reductase (MurB) reduces UDP-N-acetylglucosamine-enolpyruvate to UDP-N-acetylmuramic acid. We determined the th...

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Detalles Bibliográficos
Autores principales:	Chen, Ming Wei, Lohkamp, Bernhard, Schnell, Robert, Lescar, Julien, Schneider, Gunter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689657/ https://www.ncbi.nlm.nih.gov/pubmed/23805286 http://dx.doi.org/10.1371/journal.pone.0066936

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