Cargando…

Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe

Inositol phosphatases are important regulators of cell signaling, polarity, and vesicular trafficking. Mutations in OCRL, an inositol polyphosphate 5-phosphatase, result in Oculocerebrorenal syndrome of Lowe, an X-linked recessive disorder that presents with congenital cataracts, glaucoma, renal dys...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Na, Kumar, Akhilesh, Conwell, Michael, Weinreb, Robert N., Anderson, Ryan, Sun, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689662/ https://www.ncbi.nlm.nih.gov/pubmed/23805271 http://dx.doi.org/10.1371/journal.pone.0066727

Ejemplares similares

The inositol 5-phosphatase INPP5B regulates B cell receptor clustering and signaling
por: Droubi, Alaa, et al.
Publicado: (2022)

The inositol 5-phosphatase INPP5K participates in the fine control of ER organization
por: Dong, Rui, et al.
Publicado: (2018)

Duplicated zebrafish (Danio rerio) inositol phosphatases inpp5ka and inpp5kb diverged in expression pattern and function
por: Shukla, Dhyanam, et al.
Publicado: (2023)

OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome
por: Luo, Na, et al.
Publicado: (2012)

X-inactivation analysis of embryonic lethality in Ocrl(wt/−);Inpp5b(−/−) mice
por: Bernard, David J., et al.
Publicado: (2010)

Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway
por: Nakatsu, Fubito, et al.
Publicado: (2015)

Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family
por: Mills, Stephen J., et al.
Publicado: (2016)

Oculocerebrorenal syndrome of Lowe (OCRL) controls leukemic T-cell survival by preventing excessive PI(4,5)P(2) hydrolysis in the plasma membrane
por: Chen, Huanzhao, et al.
Publicado: (2023)

Lowe syndrome patient fibroblasts display Ocrl1-specific cell migration defects that cannot be rescued by the homologous Inpp5b phosphatase
por: Coon, Brian G., et al.
Publicado: (2009)

Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling
por: Bohdanowicz, Michal, et al.
Publicado: (2012)

INPP5E and Coordination of Signaling Networks in Cilia
por: Zhang, Renshuai, et al.
Publicado: (2022)

Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity
por: Kim, Hong Sug, et al.
Publicado: (2014)

Novel pathogenic OCRL mutations and genotype–phenotype analysis of Chinese children affected by oculocerebrorenal syndrome: two cases and a literature review
por: Zhang, Yu, et al.
Publicado: (2021)

Identification and functional analysis of a novel oculocerebrorenal syndrome of Lowe (OCRL) gene variant in two pedigrees with varying phenotypes including isolated congenital cataract
por: Shalaby, Ahmed K., et al.
Publicado: (2018)

The oculocerebrorenal syndrome of Lowe: an update
por: Bökenkamp, Arend, et al.
Publicado: (2016)

INPP5E regulates phosphoinositide-dependent cilia transition zone function
por: Dyson, Jennifer M., et al.
Publicado: (2017)

Species-specific difference in expression and splice-site choice in Inpp5b, an inositol polyphosphate 5-phosphatase paralogous to the enzyme deficient in Lowe Syndrome
por: Bothwell, Susan P., et al.
Publicado: (2010)

The Lowe syndrome protein OCRL1 is involved in primary cilia assembly
por: Hernandez, V, et al.
Publicado: (2012)

miR-181a-5p Promotes Proliferation and Invasion and Inhibits Apoptosis of Cervical Cancer Cells via Regulating Inositol Polyphosphate-5-Phosphatase A (INPP5A)
por: Yang, Meng, et al.
Publicado: (2018)

Deletion of the phosphatase INPP5E in the murine retina impairs photoreceptor axoneme formation and prevents disc morphogenesis
por: Sharif, Ali S., et al.
Publicado: (2021)

Down-Regulation of Inpp5e Associated With Abnormal Ciliogenesis During Embryonic Neurodevelopment Under Inositol Deficiency
por: Yue, Huixuan, et al.
Publicado: (2021)

Ocular Pathology of Oculocerebrorenal Syndrome of Lowe: Novel Mutations and Genotype-Phenotype Analysis
por: Song, Emilie, et al.
Publicado: (2017)

Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis
por: Xu, Qingwen, et al.
Publicado: (2016)

Expansion and Functional Divergence of Inositol Polyphosphate 5-Phosphatases in Angiosperms
por: Zhang, Zaibao, et al.
Publicado: (2019)

SdhA blocks disruption of the Legionella-containing vacuole by hijacking the OCRL phosphatase
por: Choi, Won Young, et al.
Publicado: (2021)

Mutations in the inositol polyphosphate-5-phosphatase E gene link phosphatidyl inositol signaling to the ciliopathies
por: Bielas, Stephanie L., et al.
Publicado: (2009)

Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment
por: Wiessner, Manuela, et al.
Publicado: (2017)

Identification of Inhibitors of Inositol 5-Phosphatases through Multiple Screening Strategies
por: Pirruccello, Michelle, et al.
Publicado: (2014)

INPP5D regulates inflammasome activation in human microglia
por: Chou, Vicky, et al.
Publicado: (2023)

Epigenetic Inactivation of Inositol polyphosphate 4-phosphatase B (INPP4B), a Regulator of PI3K/AKT Signaling Pathway in EBV-Associated Nasopharyngeal Carcinoma
por: Yuen, Jessie Wai-Fong, et al.
Publicado: (2014)

Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity
por: Tran, Dang Minh, et al.
Publicado: (2023)

The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics
por: Nakatsu, Fubito, et al.
Publicado: (2010)

Mechanisms controlling membrane recruitment and activation of the autoinhibited SHIP1 inositol 5-phosphatase
por: Waddell, Grace L., et al.
Publicado: (2023)

The unexpected role of Drosophila OCRL during cytokinesis
por: Ben El Kadhi, Khaled, et al.
Publicado: (2012)

A role for OCRL in glomerular function and disease
por: Preston, Rebecca, et al.
Publicado: (2019)

INPP5E Preserves Genomic Stability through Regulation of Mitosis
por: Sierra Potchanant, Elizabeth A., et al.
Publicado: (2017)

Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer’s disease
por: Castranio, Emilie L., et al.
Publicado: (2023)

Upregulation of MicroRNA-935 Promotes the Malignant Behaviors of Pancreatic Carcinoma PANC-1 Cells via Targeting Inositol Polyphosphate 4-Phosphatase Type I Gene (INPP4A)
por: Wang, Cuiyue, et al.
Publicado: (2017)

Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling
por: Yu, Jia, et al.
Publicado: (2023)

The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration
por: Kato, Katsuhiro, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_eikp6vg45hm0lp93gvo95cq9u6