A Single Nucleotide Polymorphism within the Interferon Gamma Receptor 2 Gene Perfectly Coincides with Polledness in Holstein Cattle

Polledness is a high impact trait in modern milk and beef production to meet the demands of animal welfare and work safety. Previous studies have mapped the polled-locus to the proximal region of the bovine chromosome 1 (BTA1) and narrowed it down to approximately 1 Mb. Sequencing of the positional...

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Autores principales: Glatzer, Sabrina, Merten, Nina Johanna, Dierks, Claudia, Wöhlke, Anne, Philipp, Ute, Distl, Ottmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689702/
https://www.ncbi.nlm.nih.gov/pubmed/23805331
http://dx.doi.org/10.1371/journal.pone.0067992
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author Glatzer, Sabrina
Merten, Nina Johanna
Dierks, Claudia
Wöhlke, Anne
Philipp, Ute
Distl, Ottmar
author_facet Glatzer, Sabrina
Merten, Nina Johanna
Dierks, Claudia
Wöhlke, Anne
Philipp, Ute
Distl, Ottmar
author_sort Glatzer, Sabrina
collection PubMed
description Polledness is a high impact trait in modern milk and beef production to meet the demands of animal welfare and work safety. Previous studies have mapped the polled-locus to the proximal region of the bovine chromosome 1 (BTA1) and narrowed it down to approximately 1 Mb. Sequencing of the positional candidate genes within the 1 Mb polled region and whole genome sequencing of Holsteins revealed a single nucleotide polymorphism (SNP) AC000158: g.1390292G>A within intron 3 of the interferon gamma receptor 2 gene (IFNGR2) in perfect co-segregation with polledness in Holsteins. This complete association was validated in 443 animals of the same breed. This SNP allows reliable genotyping of horned, heterozygous and homozygous polled Holsteins, even in animals that could not be resolved using the previously published haplotype for Holstein.
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spelling pubmed-36897022013-06-26 A Single Nucleotide Polymorphism within the Interferon Gamma Receptor 2 Gene Perfectly Coincides with Polledness in Holstein Cattle Glatzer, Sabrina Merten, Nina Johanna Dierks, Claudia Wöhlke, Anne Philipp, Ute Distl, Ottmar PLoS One Research Article Polledness is a high impact trait in modern milk and beef production to meet the demands of animal welfare and work safety. Previous studies have mapped the polled-locus to the proximal region of the bovine chromosome 1 (BTA1) and narrowed it down to approximately 1 Mb. Sequencing of the positional candidate genes within the 1 Mb polled region and whole genome sequencing of Holsteins revealed a single nucleotide polymorphism (SNP) AC000158: g.1390292G>A within intron 3 of the interferon gamma receptor 2 gene (IFNGR2) in perfect co-segregation with polledness in Holsteins. This complete association was validated in 443 animals of the same breed. This SNP allows reliable genotyping of horned, heterozygous and homozygous polled Holsteins, even in animals that could not be resolved using the previously published haplotype for Holstein. Public Library of Science 2013-06-21 /pmc/articles/PMC3689702/ /pubmed/23805331 http://dx.doi.org/10.1371/journal.pone.0067992 Text en © 2013 Glatzer et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Glatzer, Sabrina
Merten, Nina Johanna
Dierks, Claudia
Wöhlke, Anne
Philipp, Ute
Distl, Ottmar
A Single Nucleotide Polymorphism within the Interferon Gamma Receptor 2 Gene Perfectly Coincides with Polledness in Holstein Cattle
title A Single Nucleotide Polymorphism within the Interferon Gamma Receptor 2 Gene Perfectly Coincides with Polledness in Holstein Cattle
title_full A Single Nucleotide Polymorphism within the Interferon Gamma Receptor 2 Gene Perfectly Coincides with Polledness in Holstein Cattle
title_fullStr A Single Nucleotide Polymorphism within the Interferon Gamma Receptor 2 Gene Perfectly Coincides with Polledness in Holstein Cattle
title_full_unstemmed A Single Nucleotide Polymorphism within the Interferon Gamma Receptor 2 Gene Perfectly Coincides with Polledness in Holstein Cattle
title_short A Single Nucleotide Polymorphism within the Interferon Gamma Receptor 2 Gene Perfectly Coincides with Polledness in Holstein Cattle
title_sort single nucleotide polymorphism within the interferon gamma receptor 2 gene perfectly coincides with polledness in holstein cattle
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689702/
https://www.ncbi.nlm.nih.gov/pubmed/23805331
http://dx.doi.org/10.1371/journal.pone.0067992
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