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DISSECT Method Using PNA-LNA Clamp Improves Detection of EGFR T790m Mutation

Non-small cell lung cancer (NSCLC) patients treated with small molecule EGFR inhibitors, such as gefitinib, frequently develop drug resistance due to the presence of secondary mutations like the T790M mutation on EGFR exon 20. These mutations may originate from small subclonal populations in the pri...

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Detalles Bibliográficos
Autores principales:	Guha, Minakshi, Castellanos-Rizaldos, Elena, Makrigiorgos, G. Mike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689726/ https://www.ncbi.nlm.nih.gov/pubmed/23805327 http://dx.doi.org/10.1371/journal.pone.0067782

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