The Effect of Z-Ligustilide on the Mobility of Human Glioblastoma T98G Cells

Z-ligustilide (LIG), an essential oil extract from Radix Angelica sinensis, has broad pharmaceutical applications in treating cardio-vascular diseases and ischemic brain injury. Recently, LIG has been connected to Glioblastoma multiforme (GBM) because of its structural similarity to 3-n-alkyphthalid...

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Autores principales: Yin, Jun, Wang, Chengyuan, Mody, Aaron, Bao, Lin, Hung, Shen-Hsiu, Svoronos, Spyros A., Tseng, Yiider
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689746/
https://www.ncbi.nlm.nih.gov/pubmed/23805245
http://dx.doi.org/10.1371/journal.pone.0066598
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author Yin, Jun
Wang, Chengyuan
Mody, Aaron
Bao, Lin
Hung, Shen-Hsiu
Svoronos, Spyros A.
Tseng, Yiider
author_facet Yin, Jun
Wang, Chengyuan
Mody, Aaron
Bao, Lin
Hung, Shen-Hsiu
Svoronos, Spyros A.
Tseng, Yiider
author_sort Yin, Jun
collection PubMed
description Z-ligustilide (LIG), an essential oil extract from Radix Angelica sinensis, has broad pharmaceutical applications in treating cardio-vascular diseases and ischemic brain injury. Recently, LIG has been connected to Glioblastoma multiforme (GBM) because of its structural similarity to 3-n-alkyphthalide (NBP), which is specifically cytotoxic to GBM cells. Hence, we investigated LIG’s effect on GBM T98G cells. The study shows that LIG can significantly reduce T98G cells’ migration in a dose-dependent manner. Furthermore, the attenuation of cellular mobility can be linked to the activity of the Rho GTPases (RhoA, Rac1 and Cdc42), the three critical molecular switches governing cytoskeleton remodeling; thus, regulating cell migration. LIG significantly reduces the expression of RhoA and affects in a milder manner the expression of Cdc42 and Rac1.
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spelling pubmed-36897462013-06-26 The Effect of Z-Ligustilide on the Mobility of Human Glioblastoma T98G Cells Yin, Jun Wang, Chengyuan Mody, Aaron Bao, Lin Hung, Shen-Hsiu Svoronos, Spyros A. Tseng, Yiider PLoS One Research Article Z-ligustilide (LIG), an essential oil extract from Radix Angelica sinensis, has broad pharmaceutical applications in treating cardio-vascular diseases and ischemic brain injury. Recently, LIG has been connected to Glioblastoma multiforme (GBM) because of its structural similarity to 3-n-alkyphthalide (NBP), which is specifically cytotoxic to GBM cells. Hence, we investigated LIG’s effect on GBM T98G cells. The study shows that LIG can significantly reduce T98G cells’ migration in a dose-dependent manner. Furthermore, the attenuation of cellular mobility can be linked to the activity of the Rho GTPases (RhoA, Rac1 and Cdc42), the three critical molecular switches governing cytoskeleton remodeling; thus, regulating cell migration. LIG significantly reduces the expression of RhoA and affects in a milder manner the expression of Cdc42 and Rac1. Public Library of Science 2013-06-21 /pmc/articles/PMC3689746/ /pubmed/23805245 http://dx.doi.org/10.1371/journal.pone.0066598 Text en © 2013 Yin et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Yin, Jun
Wang, Chengyuan
Mody, Aaron
Bao, Lin
Hung, Shen-Hsiu
Svoronos, Spyros A.
Tseng, Yiider
The Effect of Z-Ligustilide on the Mobility of Human Glioblastoma T98G Cells
title The Effect of Z-Ligustilide on the Mobility of Human Glioblastoma T98G Cells
title_full The Effect of Z-Ligustilide on the Mobility of Human Glioblastoma T98G Cells
title_fullStr The Effect of Z-Ligustilide on the Mobility of Human Glioblastoma T98G Cells
title_full_unstemmed The Effect of Z-Ligustilide on the Mobility of Human Glioblastoma T98G Cells
title_short The Effect of Z-Ligustilide on the Mobility of Human Glioblastoma T98G Cells
title_sort effect of z-ligustilide on the mobility of human glioblastoma t98g cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689746/
https://www.ncbi.nlm.nih.gov/pubmed/23805245
http://dx.doi.org/10.1371/journal.pone.0066598
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