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RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED STUDY of LEPTIN ADMINISTRATION after GASTRIC BYPASS

OBJECTIVE: Obese individuals have high levels of circulating leptin and are resistant to the weight-reducing effect of leptin administration at physiological doses. Although Roux-en-Y gastric bypass (RYGB) is an effective weight loss procedure, there is a plateau in weight loss and most individuals...

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Autores principales: Korner, Judith, Conroy, Rushika, Febres, Gerardo, McMahon, Donald J., Conwell, Irene, Karmally, Wahida, Aronne, Louis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689870/
https://www.ncbi.nlm.nih.gov/pubmed/23512892
http://dx.doi.org/10.1002/oby.20433
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author Korner, Judith
Conroy, Rushika
Febres, Gerardo
McMahon, Donald J.
Conwell, Irene
Karmally, Wahida
Aronne, Louis J.
author_facet Korner, Judith
Conroy, Rushika
Febres, Gerardo
McMahon, Donald J.
Conwell, Irene
Karmally, Wahida
Aronne, Louis J.
author_sort Korner, Judith
collection PubMed
description OBJECTIVE: Obese individuals have high levels of circulating leptin and are resistant to the weight-reducing effect of leptin administration at physiological doses. Although Roux-en-Y gastric bypass (RYGB) is an effective weight loss procedure, there is a plateau in weight loss and most individuals remain obese. This plateau may be partly due to the decline in leptin resulting in a state of relative leptin insufficiency. The main objective of this study was to determine whether leptin administration to post-RYGB patients would promote further weight reduction. DESIGN AND METHODS: This was a randomized, double-blind, placebo-controlled cross-over study of 27 women who were at least 18 months post-RYGB and lost on average 30.8% of their pre-surgical body weight. Subjects received either leptin or placebo via subcutaneous injection twice daily for 16 weeks, then crossed over to receive the alternate treatment for 16 weeks. RESULTS: Weight change after 16 weeks of placebo was not significantly different from that after 16 weeks of leptin. No changes were observed in percent fat mass, resting energy expenditure, thyroid hormones, or cortisol levels. CONCLUSIONS: Contrary to our hypothesis, we did not observe a significant effect of leptin treatment on body weight in women with relative hypoleptinemia after RYGB.
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spelling pubmed-36898702013-11-01 RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED STUDY of LEPTIN ADMINISTRATION after GASTRIC BYPASS Korner, Judith Conroy, Rushika Febres, Gerardo McMahon, Donald J. Conwell, Irene Karmally, Wahida Aronne, Louis J. Obesity (Silver Spring) Article OBJECTIVE: Obese individuals have high levels of circulating leptin and are resistant to the weight-reducing effect of leptin administration at physiological doses. Although Roux-en-Y gastric bypass (RYGB) is an effective weight loss procedure, there is a plateau in weight loss and most individuals remain obese. This plateau may be partly due to the decline in leptin resulting in a state of relative leptin insufficiency. The main objective of this study was to determine whether leptin administration to post-RYGB patients would promote further weight reduction. DESIGN AND METHODS: This was a randomized, double-blind, placebo-controlled cross-over study of 27 women who were at least 18 months post-RYGB and lost on average 30.8% of their pre-surgical body weight. Subjects received either leptin or placebo via subcutaneous injection twice daily for 16 weeks, then crossed over to receive the alternate treatment for 16 weeks. RESULTS: Weight change after 16 weeks of placebo was not significantly different from that after 16 weeks of leptin. No changes were observed in percent fat mass, resting energy expenditure, thyroid hormones, or cortisol levels. CONCLUSIONS: Contrary to our hypothesis, we did not observe a significant effect of leptin treatment on body weight in women with relative hypoleptinemia after RYGB. 2013-05 /pmc/articles/PMC3689870/ /pubmed/23512892 http://dx.doi.org/10.1002/oby.20433 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Korner, Judith
Conroy, Rushika
Febres, Gerardo
McMahon, Donald J.
Conwell, Irene
Karmally, Wahida
Aronne, Louis J.
RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED STUDY of LEPTIN ADMINISTRATION after GASTRIC BYPASS
title RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED STUDY of LEPTIN ADMINISTRATION after GASTRIC BYPASS
title_full RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED STUDY of LEPTIN ADMINISTRATION after GASTRIC BYPASS
title_fullStr RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED STUDY of LEPTIN ADMINISTRATION after GASTRIC BYPASS
title_full_unstemmed RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED STUDY of LEPTIN ADMINISTRATION after GASTRIC BYPASS
title_short RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED STUDY of LEPTIN ADMINISTRATION after GASTRIC BYPASS
title_sort randomized double-blind placebo-controlled study of leptin administration after gastric bypass
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689870/
https://www.ncbi.nlm.nih.gov/pubmed/23512892
http://dx.doi.org/10.1002/oby.20433
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