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Hemodynamic Reactivity to Laboratory Stressors in Healthy Subjects: Influence of Gender and Family History of Cardiovascular Diseases

Although laboratory stressor tests have been applied as a preliminary protocol in some cardiovascular studies, there is a lack of data comparing the pressor and chronotropic responses among the main stressor tests. Therefore, the aim of this study was to evaluate the variability in hemodynamic respo...

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Autores principales: Simoes, Giovana M. S., Campagnaro, Bianca P., Tonini, Clarissa L., Meyrelles, Silvana S., Kuniyoshi, Fatima H. Sert, Vasquez, Elisardo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689876/
https://www.ncbi.nlm.nih.gov/pubmed/23794949
http://dx.doi.org/10.7150/ijms.5967
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author Simoes, Giovana M. S.
Campagnaro, Bianca P.
Tonini, Clarissa L.
Meyrelles, Silvana S.
Kuniyoshi, Fatima H. Sert
Vasquez, Elisardo C.
author_facet Simoes, Giovana M. S.
Campagnaro, Bianca P.
Tonini, Clarissa L.
Meyrelles, Silvana S.
Kuniyoshi, Fatima H. Sert
Vasquez, Elisardo C.
author_sort Simoes, Giovana M. S.
collection PubMed
description Although laboratory stressor tests have been applied as a preliminary protocol in some cardiovascular studies, there is a lack of data comparing the pressor and chronotropic responses among the main stressor tests. Therefore, the aim of this study was to evaluate the variability in hemodynamic responsiveness to the main stressor tests, establish a hyperresponsiveness cutoff criterion and analyze the influence of gender and family history of cardiovascular diseases (CVDs) in healthy subjects. We examined hemodynamic responses to physical (cold pressor and handgrip tests) and mental (Stroop color-word test) stressors in 98 subjects (48 males and 50 females) without CVDs. All stressor tests resulted in increased blood pressure (BP) levels, which were lower and less dispersed in the handgrip test compared to the cold pressor test. Adopting the 75(th) percentile as the cutoff in our data, we classified subjects exhibiting absolute pressor changes equal to or higher than 14, 24 and 36 mmHg in systolic and 9, 13 and 24 mmHg in diastolic BP during the handgrip, Stroop and cold pressor test, respectively, as hyperresponsives. Males exhibited greater (p<0.05) increases in systolic BP in the handgrip (11% vs. 8%) and cold pressor (25% vs. 21%) tests and in diastolic BP in the handgrip (12% vs. 7%) and Stroop (22% vs. 19%) tests than females. A positive association between family history of CVDs and pressor hyperreactivity to stressor tests was observed. We propose using the 75(th) percentile of hemodynamic sample values as a cutoff criterion to classify individuals as pressor or chronotropic hyperreactives. We conclude that hemodynamic responsiveness to stressor tests in healthy subjects is positively influenced by male gender and family history of CVDs.
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spelling pubmed-36898762013-06-23 Hemodynamic Reactivity to Laboratory Stressors in Healthy Subjects: Influence of Gender and Family History of Cardiovascular Diseases Simoes, Giovana M. S. Campagnaro, Bianca P. Tonini, Clarissa L. Meyrelles, Silvana S. Kuniyoshi, Fatima H. Sert Vasquez, Elisardo C. Int J Med Sci Research Paper Although laboratory stressor tests have been applied as a preliminary protocol in some cardiovascular studies, there is a lack of data comparing the pressor and chronotropic responses among the main stressor tests. Therefore, the aim of this study was to evaluate the variability in hemodynamic responsiveness to the main stressor tests, establish a hyperresponsiveness cutoff criterion and analyze the influence of gender and family history of cardiovascular diseases (CVDs) in healthy subjects. We examined hemodynamic responses to physical (cold pressor and handgrip tests) and mental (Stroop color-word test) stressors in 98 subjects (48 males and 50 females) without CVDs. All stressor tests resulted in increased blood pressure (BP) levels, which were lower and less dispersed in the handgrip test compared to the cold pressor test. Adopting the 75(th) percentile as the cutoff in our data, we classified subjects exhibiting absolute pressor changes equal to or higher than 14, 24 and 36 mmHg in systolic and 9, 13 and 24 mmHg in diastolic BP during the handgrip, Stroop and cold pressor test, respectively, as hyperresponsives. Males exhibited greater (p<0.05) increases in systolic BP in the handgrip (11% vs. 8%) and cold pressor (25% vs. 21%) tests and in diastolic BP in the handgrip (12% vs. 7%) and Stroop (22% vs. 19%) tests than females. A positive association between family history of CVDs and pressor hyperreactivity to stressor tests was observed. We propose using the 75(th) percentile of hemodynamic sample values as a cutoff criterion to classify individuals as pressor or chronotropic hyperreactives. We conclude that hemodynamic responsiveness to stressor tests in healthy subjects is positively influenced by male gender and family history of CVDs. Ivyspring International Publisher 2013-05-08 /pmc/articles/PMC3689876/ /pubmed/23794949 http://dx.doi.org/10.7150/ijms.5967 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Research Paper
Simoes, Giovana M. S.
Campagnaro, Bianca P.
Tonini, Clarissa L.
Meyrelles, Silvana S.
Kuniyoshi, Fatima H. Sert
Vasquez, Elisardo C.
Hemodynamic Reactivity to Laboratory Stressors in Healthy Subjects: Influence of Gender and Family History of Cardiovascular Diseases
title Hemodynamic Reactivity to Laboratory Stressors in Healthy Subjects: Influence of Gender and Family History of Cardiovascular Diseases
title_full Hemodynamic Reactivity to Laboratory Stressors in Healthy Subjects: Influence of Gender and Family History of Cardiovascular Diseases
title_fullStr Hemodynamic Reactivity to Laboratory Stressors in Healthy Subjects: Influence of Gender and Family History of Cardiovascular Diseases
title_full_unstemmed Hemodynamic Reactivity to Laboratory Stressors in Healthy Subjects: Influence of Gender and Family History of Cardiovascular Diseases
title_short Hemodynamic Reactivity to Laboratory Stressors in Healthy Subjects: Influence of Gender and Family History of Cardiovascular Diseases
title_sort hemodynamic reactivity to laboratory stressors in healthy subjects: influence of gender and family history of cardiovascular diseases
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689876/
https://www.ncbi.nlm.nih.gov/pubmed/23794949
http://dx.doi.org/10.7150/ijms.5967
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