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Biosensors in Clinical Practice: Focus on Oncohematology
Biosensors are devices that are capable of detecting specific biological analytes and converting their presence or concentration into some electrical, thermal, optical or other signal that can be easily analysed. The first biosensor was designed by Clark and Lyons in 1962 as a means of measuring glu...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690064/ https://www.ncbi.nlm.nih.gov/pubmed/23673681 http://dx.doi.org/10.3390/s130506423 |
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author | Fracchiolla, Nicola S. Artuso, Silvia Cortelezzi, Agostino |
author_facet | Fracchiolla, Nicola S. Artuso, Silvia Cortelezzi, Agostino |
author_sort | Fracchiolla, Nicola S. |
collection | PubMed |
description | Biosensors are devices that are capable of detecting specific biological analytes and converting their presence or concentration into some electrical, thermal, optical or other signal that can be easily analysed. The first biosensor was designed by Clark and Lyons in 1962 as a means of measuring glucose. Since then, much progress has been made and the applications of biosensors are today potentially boundless. This review is limited to their clinical applications, particularly in the field of oncohematology. Biosensors have recently been developed in order to improve the diagnosis and treatment of patients affected by hematological malignancies, such as the biosensor for assessing the in vitro pre-treatment efficacy of cytarabine in acute myeloid leukemia, and the fluorescence resonance energy transfer-based biosensor for assessing the efficacy of imatinib in chronic myeloid leukemia. The review also considers the challenges and future perspectives of biosensors in clinical practice. |
format | Online Article Text |
id | pubmed-3690064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-36900642013-07-09 Biosensors in Clinical Practice: Focus on Oncohematology Fracchiolla, Nicola S. Artuso, Silvia Cortelezzi, Agostino Sensors (Basel) Review Biosensors are devices that are capable of detecting specific biological analytes and converting their presence or concentration into some electrical, thermal, optical or other signal that can be easily analysed. The first biosensor was designed by Clark and Lyons in 1962 as a means of measuring glucose. Since then, much progress has been made and the applications of biosensors are today potentially boundless. This review is limited to their clinical applications, particularly in the field of oncohematology. Biosensors have recently been developed in order to improve the diagnosis and treatment of patients affected by hematological malignancies, such as the biosensor for assessing the in vitro pre-treatment efficacy of cytarabine in acute myeloid leukemia, and the fluorescence resonance energy transfer-based biosensor for assessing the efficacy of imatinib in chronic myeloid leukemia. The review also considers the challenges and future perspectives of biosensors in clinical practice. Molecular Diversity Preservation International (MDPI) 2013-05-14 /pmc/articles/PMC3690064/ /pubmed/23673681 http://dx.doi.org/10.3390/s130506423 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Review Fracchiolla, Nicola S. Artuso, Silvia Cortelezzi, Agostino Biosensors in Clinical Practice: Focus on Oncohematology |
title | Biosensors in Clinical Practice: Focus on Oncohematology |
title_full | Biosensors in Clinical Practice: Focus on Oncohematology |
title_fullStr | Biosensors in Clinical Practice: Focus on Oncohematology |
title_full_unstemmed | Biosensors in Clinical Practice: Focus on Oncohematology |
title_short | Biosensors in Clinical Practice: Focus on Oncohematology |
title_sort | biosensors in clinical practice: focus on oncohematology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690064/ https://www.ncbi.nlm.nih.gov/pubmed/23673681 http://dx.doi.org/10.3390/s130506423 |
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