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IGF-I attenuates FFA-induced activation of JNK1 phosphorylation and TNFα expression in human subcutaneous preadipocytes

OBJECTIVE: Free fatty acids (FFAs) are increased in visceral fat and contribute to insulin resistance through multiple mechanisms, including c-Jun N-terminal kinase (JNK) activation and expression of TNFα. Given that IGF-I-mediated proliferation is impaired in omental compared to subcutaneous (sc) p...

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Detalles Bibliográficos
Autores principales:	Neacsu, Otilia, Cleveland, Kelly, Xu, Haiyan, Tchkonia, Tamara T., Kirkland, James L, Boney, Charlotte M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690156/ https://www.ncbi.nlm.nih.gov/pubmed/23512893 http://dx.doi.org/10.1002/oby.20329

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