Cargando…
TrkAIII Promotes Microtubule Nucleation and Assembly at the Centrosome in SH-SY5Y Neuroblastoma Cells, Contributing to an Undifferentiated Anaplastic Phenotype
The alternative TrkAIII splice variant is expressed by advanced stage human neuroblastomas (NBs) and exhibits oncogenic activity in NB models. In the present study, employing stable transfected cell lines and assays of indirect immunofluorescence, immunoprecipitation, Western blotting, microtubule r...
Autores principales: | Farina, Antonietta R., Di Ianni, Natalia, Cappabianca, Lucia, Ruggeri, Pierdomenico, Ragone, Marzia, Ianni, Giulia, Gulino, Alberto, Mackay, Andrew R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690223/ https://www.ncbi.nlm.nih.gov/pubmed/23841091 http://dx.doi.org/10.1155/2013/740187 |
Ejemplares similares
-
TRAIL induces pro-apoptotic crosstalk between the TRAIL-receptor signaling pathway and TrkAIII in SH-SY5Y cells, unveiling a potential therapeutic “Achilles heel” for the TrkAIII oncoprotein in neuroblastoma
por: Gneo, Luciana, et al.
Publicado: (2016) -
The TrkAIII Oncoprotein Inhibits Mitochondrial Free Radical ROS-Induced Death of SH-SY5Y Neuroblastoma Cells by Augmenting SOD2 Expression and Activity at the Mitochondria, within the Context of a Tumour Stem Cell-like Phenotype
por: Ruggeri, Pierdomenico, et al.
Publicado: (2014) -
The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII
por: Farina, Antonietta Rosella, et al.
Publicado: (2018) -
TrkAIII signals endoplasmic reticulum stress to the mitochondria in neuroblastoma cells, resulting in glycolytic metabolic adaptation
por: Farina, Antonietta Rosella, et al.
Publicado: (2017) -
Retrograde TrkAIII transport from ERGIC to ER: a re-localisation mechanism for oncogenic activity
por: Farina, Antonietta Rosella, et al.
Publicado: (2015)