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High-Dose, but Not Low-Dose, Aspirin Impairs Anticontractile Effect of Ticagrelor following ADP Stimulation in Rat Tail Artery Smooth Muscle Cells
Objective. To compare effects of low- versus high-dose aspirin coadministered with ticagrelor on the reactivity of vascular smooth muscle cells (VSMCs). Methods. Wistar rats were orally administered ticagrelor (10 mg/kg) and/or aspirin (2 or 10 mg/kg) (n = 7 per each of 4 groups) or placebo (n = 9)...
Autores principales: | Grześk, Grzegorz, Kozinski, Marek, Tantry, Udaya S., Wicinski, Michal, Fabiszak, Tomasz, Navarese, Eliano P., Grzesk, Elzbieta, Jeong, Young-Hoon, Gurbel, Paul A., Kubica, Jacek |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690229/ https://www.ncbi.nlm.nih.gov/pubmed/23841099 http://dx.doi.org/10.1155/2013/928271 |
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