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Aggressive Treatment of Patients with Metastatic Colorectal Cancer Increases Survival: A Scandinavian Single-Center Experience
Background. We examined overall and disease-free survivals in a cohort of patients subjected to resection of liver metastasis from colorectal cancer (CRLM) in a 10-year period when new treatment strategies were implemented. Methods. Data from 239 consecutive patients selected for liver resection of...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690245/ https://www.ncbi.nlm.nih.gov/pubmed/23840074 http://dx.doi.org/10.1155/2013/727095 |
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author | Brudvik, Kristoffer Watten Bains, Simer Jit Seeberg, Lars Thomas Labori, Knut Jørgen Waage, Anne Taskén, Kjetil Aandahl, Einar Martin Bjørnbeth, Bjørn Atle |
author_facet | Brudvik, Kristoffer Watten Bains, Simer Jit Seeberg, Lars Thomas Labori, Knut Jørgen Waage, Anne Taskén, Kjetil Aandahl, Einar Martin Bjørnbeth, Bjørn Atle |
author_sort | Brudvik, Kristoffer Watten |
collection | PubMed |
description | Background. We examined overall and disease-free survivals in a cohort of patients subjected to resection of liver metastasis from colorectal cancer (CRLM) in a 10-year period when new treatment strategies were implemented. Methods. Data from 239 consecutive patients selected for liver resection of CRLM during the period from 2002 to 2011 at a single center were used to estimate overall and disease-free survival. The results were assessed against new treatment strategies and established risk factors. Results. The 5-year cumulative overall and disease-free survivals were 46 and 24%. The overall survival was the same after reresection, independently of the number of prior resections and irrespectively of the location of the recurrent disease. The time intervals between each recurrence were similar (11 ± 1 months). Patients with high tumor load given neoadjuvant chemotherapy had comparable survival to those with less extensive disease without neoadjuvant chemotherapy. Positive resection margin or resectable extrahepatic disease did not affect overall survival. Conclusion. Our data support that one still, and perhaps to an even greater extent, should seek an aggressive therapeutic strategy to achieve resectable status for recurrent hepatic and extrahepatic metastases. The data should be viewed in the context of recent advances in the understanding of cancer biology and the metastatic process. |
format | Online Article Text |
id | pubmed-3690245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36902452013-07-09 Aggressive Treatment of Patients with Metastatic Colorectal Cancer Increases Survival: A Scandinavian Single-Center Experience Brudvik, Kristoffer Watten Bains, Simer Jit Seeberg, Lars Thomas Labori, Knut Jørgen Waage, Anne Taskén, Kjetil Aandahl, Einar Martin Bjørnbeth, Bjørn Atle HPB Surg Research Article Background. We examined overall and disease-free survivals in a cohort of patients subjected to resection of liver metastasis from colorectal cancer (CRLM) in a 10-year period when new treatment strategies were implemented. Methods. Data from 239 consecutive patients selected for liver resection of CRLM during the period from 2002 to 2011 at a single center were used to estimate overall and disease-free survival. The results were assessed against new treatment strategies and established risk factors. Results. The 5-year cumulative overall and disease-free survivals were 46 and 24%. The overall survival was the same after reresection, independently of the number of prior resections and irrespectively of the location of the recurrent disease. The time intervals between each recurrence were similar (11 ± 1 months). Patients with high tumor load given neoadjuvant chemotherapy had comparable survival to those with less extensive disease without neoadjuvant chemotherapy. Positive resection margin or resectable extrahepatic disease did not affect overall survival. Conclusion. Our data support that one still, and perhaps to an even greater extent, should seek an aggressive therapeutic strategy to achieve resectable status for recurrent hepatic and extrahepatic metastases. The data should be viewed in the context of recent advances in the understanding of cancer biology and the metastatic process. Hindawi Publishing Corporation 2013 2013-06-06 /pmc/articles/PMC3690245/ /pubmed/23840074 http://dx.doi.org/10.1155/2013/727095 Text en Copyright © 2013 Kristoffer Watten Brudvik et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Brudvik, Kristoffer Watten Bains, Simer Jit Seeberg, Lars Thomas Labori, Knut Jørgen Waage, Anne Taskén, Kjetil Aandahl, Einar Martin Bjørnbeth, Bjørn Atle Aggressive Treatment of Patients with Metastatic Colorectal Cancer Increases Survival: A Scandinavian Single-Center Experience |
title | Aggressive Treatment of Patients with Metastatic Colorectal Cancer Increases Survival: A Scandinavian Single-Center Experience |
title_full | Aggressive Treatment of Patients with Metastatic Colorectal Cancer Increases Survival: A Scandinavian Single-Center Experience |
title_fullStr | Aggressive Treatment of Patients with Metastatic Colorectal Cancer Increases Survival: A Scandinavian Single-Center Experience |
title_full_unstemmed | Aggressive Treatment of Patients with Metastatic Colorectal Cancer Increases Survival: A Scandinavian Single-Center Experience |
title_short | Aggressive Treatment of Patients with Metastatic Colorectal Cancer Increases Survival: A Scandinavian Single-Center Experience |
title_sort | aggressive treatment of patients with metastatic colorectal cancer increases survival: a scandinavian single-center experience |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690245/ https://www.ncbi.nlm.nih.gov/pubmed/23840074 http://dx.doi.org/10.1155/2013/727095 |
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