Cargando…

NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy

Alzheimer's disease (AD) is a devastating neurodegenerative disease causing irreversible cognitive decline in the elderly. There is no disease-modifying therapy for this condition and the mechanisms underpinning neuronal dysfunction and neurodegeneration are unclear. Compromised cytoskeletal in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Quraishe, S, Cowan, C M, Mudher, A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690421/ https://www.ncbi.nlm.nih.gov/pubmed/23587881 http://dx.doi.org/10.1038/mp.2013.32

Ejemplares similares

Modelling Tauopathies in Drosophila: Insights from the Fruit Fly
por: Cowan, Catherine M., et al.
Publicado: (2011)

NAP (davunetide) preferential interaction with dynamic 3-repeat Tau explains differential protection in selected tauopathies
por: Ivashko-Pachima, Yanina, et al.
Publicado: (2019)

Impairment of mitochondria dynamics by human A53T α-synuclein and rescue by NAP (davunetide) in a cell model for Parkinson’s disease
por: Melo, T. Q., et al.
Publicado: (2016)

Rescue from tau-induced neuronal dysfunction produces insoluble tau oligomers
por: Cowan, Catherine M., et al.
Publicado: (2015)

NAP (Davunetide): The Neuroprotective ADNP Drug Candidate Penetrates Cell Nuclei Explaining Pleiotropic Mechanisms
por: Ganaiem, Maram, et al.
Publicado: (2023)

Intranasal NAP (davunetide) decreases tau hyperphosphorylation and moderately improves behavioral deficits in mice overexpressing α-synuclein
por: Magen, Iddo, et al.
Publicado: (2014)

Microtubule stabilising peptides rescue tau phenotypes in-vivo
por: Quraishe, Shmma, et al.
Publicado: (2016)

Corrigendum: Microtubule stabilising peptides rescue tau phenotypes in-vivo
por: Quraishe, Shmma, et al.
Publicado: (2017)

Are Tau Aggregates Toxic or Protective in Tauopathies?
por: Cowan, Catherine M., et al.
Publicado: (2013)

Insulin-Mediated Changes in Tau Hyperphosphorylation and Autophagy in a Drosophila Model of Tauopathy and Neuroblastoma Cells
por: Chatterjee, Shreyasi, et al.
Publicado: (2019)

Critical appraisal of the role of davunetide in the treatment of progressive supranuclear palsy
por: Gold, Michael, et al.
Publicado: (2012)

Unexpected gender differences in progressive supranuclear palsy reveal efficacy for davunetide in women
por: Gozes, Illana, et al.
Publicado: (2023)

Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy
por: Chang, Ching-Pang, et al.
Publicado: (2021)

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons
por: Silva, M. Catarina, et al.
Publicado: (2020)

Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy
por: Koren, Shon A., et al.
Publicado: (2021)

Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models
por: Malmanche, Nicolas, et al.
Publicado: (2017)

Drosophila Models of Tauopathies: What Have We Learned?
por: Gistelinck, Marc, et al.
Publicado: (2012)

Associations Between Amantadine Usage, Gait, and Cognition in PSP: A post-hoc Analysis of the Davunetide Trial
por: Dale, Marian L., et al.
Publicado: (2020)

Glial tauopathy: Neurons optional?
por: Walker, Lary C.
Publicado: (2019)

Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of Tauopathy
por: Miyasaka, Tomohiro, et al.
Publicado: (2018)

Distinctive alteration in the expression of autophagy genes in Drosophila models of amyloidopathy and tauopathy
por: Haghi, Mehrnaz, et al.
Publicado: (2020)

Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau
por: Wu, Ting-Han, et al.
Publicado: (2013)

Drosophila modelling axonal transport in the face of tau pathology
por: Mudher, Amrit
Publicado: (2015)

Dysfunction of the glutamatergic photoreceptor synapse in the P301S mouse model of tauopathy
por: Arouche-Delaperche, L., et al.
Publicado: (2023)

Grape-Seed Polyphenolic Extract Improves the Eye Phenotype in a Drosophila Model of Tauopathy
por: Pfleger, Cathie M., et al.
Publicado: (2010)

Glucose deficit triggers tau pathology and synaptic dysfunction in a tauopathy mouse model
por: Lauretti, E, et al.
Publicado: (2017)

Tau Spreading Mechanisms; Implications for Dysfunctional Tauopathies
por: Fuster-Matanzo, Almudena, et al.
Publicado: (2018)

Altered Gut Microbial Load and Immune Activation in a Drosophila Model of Human Tauopathy
por: Rydbom, Jerrik, et al.
Publicado: (2021)

PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy
por: Benetatos, Joseph, et al.
Publicado: (2020)

Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model
por: Williams, Jamal B., et al.
Publicado: (2023)

SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy
por: Muñiz, Javier Andrés, et al.
Publicado: (2022)

Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate
por: Bondulich, Marie K., et al.
Publicado: (2016)

Pentamidine rescues contractility and rhythmicity in a Drosophila model of myotonic dystrophy heart dysfunction
por: Chakraborty, Mouli, et al.
Publicado: (2015)

Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy
por: Ferrer, Isidro, et al.
Publicado: (2020)

Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model
por: Rickner, Hannah Drew, et al.
Publicado: (2022)

NITRIC OXIDE SYNTHASE DYSFUNCTION UNDERLIES CEREBROVASCULAR DEFICITS IN A MOUSE MODEL OF TAUOPATHY
por: Van Skike, Candice E, et al.
Publicado: (2019)

Non-Rodent Genetic Animal Models for Studying Tauopathy: Review of Drosophila, Zebrafish, and C. elegans Models
por: Giong, Hoi-Khoanh, et al.
Publicado: (2021)

Drosophila Spaghetti and Doubletime Link the Circadian Clock and Light to Caspases, Apoptosis and Tauopathy
por: Means, John C., et al.
Publicado: (2015)

To Nap or Not to Nap? A Systematic Review Evaluating Napping Behavior in Athletes and the Impact on Various Measures of Athletic Performance
por: Lastella, Michele, et al.
Publicado: (2021)

Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington's disease
por: Steinert, Joern R., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_u25u2tli8vt936jen3rcis3rfm