RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms

RAS proteins are important direct activators of p110α, p110γ, and p110δ type I phosphoinositide 3-kinases (PI3Ks), interacting via an amino-terminal RAS-binding domain (RBD). Here, we investigate the regulation of the ubiquitous p110β isoform of PI3K, implicated in G-protein-coupled receptor (GPCR)...

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Detalles Bibliográficos
Autores principales: Fritsch, Ralph, de Krijger, Inge, Fritsch, Kornelia, George, Roger, Reason, Beth, Kumar, Madhu S., Diefenbacher, Markus, Stamp, Gordon, Downward, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690480/
https://www.ncbi.nlm.nih.gov/pubmed/23706742
http://dx.doi.org/10.1016/j.cell.2013.04.031

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