Cargando…

Oxidant Status and Lipid Composition of Erythrocyte Membranes in Patients with Type 2 Diabetes, Chronic Liver Damage, and a Combination of Both Pathologies

There is an important set of cirrhotic and diabetic patients that present both diseases. However, information about metabolic and cellular blood markers that are altered, in conjunction or distinctively, in the 3 pathological conditions is scarce. The aim of this project was to evaluate several indi...

Descripción completa

Detalles Bibliográficos
Autores principales: Hernández-Muñoz, Rolando, Olguín-Martínez, Marisela, Aguilar-Delfín, Irma, Sánchez-Sevilla, Lourdes, García-García, Norberto, Díaz-Muñoz, Mauricio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690744/
https://www.ncbi.nlm.nih.gov/pubmed/23840919
http://dx.doi.org/10.1155/2013/657387
_version_ 1782274398227529728
author Hernández-Muñoz, Rolando
Olguín-Martínez, Marisela
Aguilar-Delfín, Irma
Sánchez-Sevilla, Lourdes
García-García, Norberto
Díaz-Muñoz, Mauricio
author_facet Hernández-Muñoz, Rolando
Olguín-Martínez, Marisela
Aguilar-Delfín, Irma
Sánchez-Sevilla, Lourdes
García-García, Norberto
Díaz-Muñoz, Mauricio
author_sort Hernández-Muñoz, Rolando
collection PubMed
description There is an important set of cirrhotic and diabetic patients that present both diseases. However, information about metabolic and cellular blood markers that are altered, in conjunction or distinctively, in the 3 pathological conditions is scarce. The aim of this project was to evaluate several indicators of prooxidant reactions and the membrane composition of blood samples (serum and red blood cells (RBCs)) from patients clinically classified as diabetic (n = 60), cirrhotic (n = 70), and diabetic with liver cirrhosis (n = 25) as compared to samples from a similar population of healthy individuals (n = 60). The results showed that levels of TBARS, nitrites, cysteine, and conjugated dienes in the RBC of cirrhotic patients were significantly increased. However, the coincidence of diabetes and cirrhosis partially reduced the alterations promoted by the cirrhotic condition. The amount of total phospholipids and cholesterol was greatly enhanced in the patients with both pathologies (between 60 and 200% according to the type of phospholipid) but not in the patients with only one disease. Overall, the data indicate that the cooccurrence of diabetes and cirrhosis elicits a physiopathological equilibrium that is different from the alterations typical of each individual malady.
format Online
Article
Text
id pubmed-3690744
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-36907442013-07-09 Oxidant Status and Lipid Composition of Erythrocyte Membranes in Patients with Type 2 Diabetes, Chronic Liver Damage, and a Combination of Both Pathologies Hernández-Muñoz, Rolando Olguín-Martínez, Marisela Aguilar-Delfín, Irma Sánchez-Sevilla, Lourdes García-García, Norberto Díaz-Muñoz, Mauricio Oxid Med Cell Longev Clinical Study There is an important set of cirrhotic and diabetic patients that present both diseases. However, information about metabolic and cellular blood markers that are altered, in conjunction or distinctively, in the 3 pathological conditions is scarce. The aim of this project was to evaluate several indicators of prooxidant reactions and the membrane composition of blood samples (serum and red blood cells (RBCs)) from patients clinically classified as diabetic (n = 60), cirrhotic (n = 70), and diabetic with liver cirrhosis (n = 25) as compared to samples from a similar population of healthy individuals (n = 60). The results showed that levels of TBARS, nitrites, cysteine, and conjugated dienes in the RBC of cirrhotic patients were significantly increased. However, the coincidence of diabetes and cirrhosis partially reduced the alterations promoted by the cirrhotic condition. The amount of total phospholipids and cholesterol was greatly enhanced in the patients with both pathologies (between 60 and 200% according to the type of phospholipid) but not in the patients with only one disease. Overall, the data indicate that the cooccurrence of diabetes and cirrhosis elicits a physiopathological equilibrium that is different from the alterations typical of each individual malady. Hindawi Publishing Corporation 2013 2013-06-06 /pmc/articles/PMC3690744/ /pubmed/23840919 http://dx.doi.org/10.1155/2013/657387 Text en Copyright © 2013 Rolando Hernández-Muñoz et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Hernández-Muñoz, Rolando
Olguín-Martínez, Marisela
Aguilar-Delfín, Irma
Sánchez-Sevilla, Lourdes
García-García, Norberto
Díaz-Muñoz, Mauricio
Oxidant Status and Lipid Composition of Erythrocyte Membranes in Patients with Type 2 Diabetes, Chronic Liver Damage, and a Combination of Both Pathologies
title Oxidant Status and Lipid Composition of Erythrocyte Membranes in Patients with Type 2 Diabetes, Chronic Liver Damage, and a Combination of Both Pathologies
title_full Oxidant Status and Lipid Composition of Erythrocyte Membranes in Patients with Type 2 Diabetes, Chronic Liver Damage, and a Combination of Both Pathologies
title_fullStr Oxidant Status and Lipid Composition of Erythrocyte Membranes in Patients with Type 2 Diabetes, Chronic Liver Damage, and a Combination of Both Pathologies
title_full_unstemmed Oxidant Status and Lipid Composition of Erythrocyte Membranes in Patients with Type 2 Diabetes, Chronic Liver Damage, and a Combination of Both Pathologies
title_short Oxidant Status and Lipid Composition of Erythrocyte Membranes in Patients with Type 2 Diabetes, Chronic Liver Damage, and a Combination of Both Pathologies
title_sort oxidant status and lipid composition of erythrocyte membranes in patients with type 2 diabetes, chronic liver damage, and a combination of both pathologies
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690744/
https://www.ncbi.nlm.nih.gov/pubmed/23840919
http://dx.doi.org/10.1155/2013/657387
work_keys_str_mv AT hernandezmunozrolando oxidantstatusandlipidcompositionoferythrocytemembranesinpatientswithtype2diabeteschronicliverdamageandacombinationofbothpathologies
AT olguinmartinezmarisela oxidantstatusandlipidcompositionoferythrocytemembranesinpatientswithtype2diabeteschronicliverdamageandacombinationofbothpathologies
AT aguilardelfinirma oxidantstatusandlipidcompositionoferythrocytemembranesinpatientswithtype2diabeteschronicliverdamageandacombinationofbothpathologies
AT sanchezsevillalourdes oxidantstatusandlipidcompositionoferythrocytemembranesinpatientswithtype2diabeteschronicliverdamageandacombinationofbothpathologies
AT garciagarcianorberto oxidantstatusandlipidcompositionoferythrocytemembranesinpatientswithtype2diabeteschronicliverdamageandacombinationofbothpathologies
AT diazmunozmauricio oxidantstatusandlipidcompositionoferythrocytemembranesinpatientswithtype2diabeteschronicliverdamageandacombinationofbothpathologies