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Evaluation of acute/late toxicity and local recurrence in T1–T2 glottic carcinoma treated with accelerated hypofractionated 3D-conformal external beam radiotherapy (3D-CRT)

BACKGROUND: The aim of the study was to evaluate the efficacy, as well as the acute and late toxicity of an accelerated hypofractionated 3DCRT schedule as radical treatment in patients with organ confined glottic cancer cT1-2N0. PATIENTS AND METHODS. Between June of 2004 and September 2010, 47 retro...

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Autores principales: Kouloulias, Vassilis E., Zygogianni, Anna, Mosa, Eftychia, Platoni, Kalliopi, Georgakopoulos, John, Antypas, Christos, Beli, Ivelina, Tolia, Maria, Maragoudakis, Paulos, Giotakis, Ioannis, Papas, Zisis, Psyrri, Amanda, Kelekis, Nikolaos, Kouvaris, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Versita, Warsaw 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691085/
https://www.ncbi.nlm.nih.gov/pubmed/23801916
http://dx.doi.org/10.2478/raon-2013-0020
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author Kouloulias, Vassilis E.
Zygogianni, Anna
Mosa, Eftychia
Platoni, Kalliopi
Georgakopoulos, John
Antypas, Christos
Beli, Ivelina
Tolia, Maria
Maragoudakis, Paulos
Giotakis, Ioannis
Papas, Zisis
Psyrri, Amanda
Kelekis, Nikolaos
Kouvaris, John
author_facet Kouloulias, Vassilis E.
Zygogianni, Anna
Mosa, Eftychia
Platoni, Kalliopi
Georgakopoulos, John
Antypas, Christos
Beli, Ivelina
Tolia, Maria
Maragoudakis, Paulos
Giotakis, Ioannis
Papas, Zisis
Psyrri, Amanda
Kelekis, Nikolaos
Kouvaris, John
author_sort Kouloulias, Vassilis E.
collection PubMed
description BACKGROUND: The aim of the study was to evaluate the efficacy, as well as the acute and late toxicity of an accelerated hypofractionated 3DCRT schedule as radical treatment in patients with organ confined glottic cancer cT1-2N0. PATIENTS AND METHODS. Between June of 2004 and September 2010, 47 retrospectively selected patients (29 males, 18 females) diagnosed with organ confined T1 or T2 glottic cancer, were treated with external 3DCRT in an accelerated hypofractionation schedule. The median age was 70 years. A dose of 64.4 Gy in 28 daily fractions was prescribed. The primary study endpoints were to assess the acute and late effects of radiation toxicity, according to the EORTC/ RTOG scale, as well as the therapeutic impact of this schedule in terms of local recurrence. RESULTS: The median follow up was 36 months. At the end of radiotherapy, grade I, II and III acute toxicity was observed in 34, 9 and4 patients, respectively. Late grade I and II toxicity was observed in 25 and in 8 patients respectively. Only two local recurrences were observed, 15 and 24 months post 3DCRT respectively. CONCLUSIONS: Our radiotherapy schedule achieves a high locoregional control rate with the advantage of voice preservation. The proposed hypofractionated schedule can be recommended as a standard radiotherapy treatment, since these results are comparable with those of conventional fractionation schedules.
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spelling pubmed-36910852013-06-25 Evaluation of acute/late toxicity and local recurrence in T1–T2 glottic carcinoma treated with accelerated hypofractionated 3D-conformal external beam radiotherapy (3D-CRT) Kouloulias, Vassilis E. Zygogianni, Anna Mosa, Eftychia Platoni, Kalliopi Georgakopoulos, John Antypas, Christos Beli, Ivelina Tolia, Maria Maragoudakis, Paulos Giotakis, Ioannis Papas, Zisis Psyrri, Amanda Kelekis, Nikolaos Kouvaris, John Radiol Oncol Research Article BACKGROUND: The aim of the study was to evaluate the efficacy, as well as the acute and late toxicity of an accelerated hypofractionated 3DCRT schedule as radical treatment in patients with organ confined glottic cancer cT1-2N0. PATIENTS AND METHODS. Between June of 2004 and September 2010, 47 retrospectively selected patients (29 males, 18 females) diagnosed with organ confined T1 or T2 glottic cancer, were treated with external 3DCRT in an accelerated hypofractionation schedule. The median age was 70 years. A dose of 64.4 Gy in 28 daily fractions was prescribed. The primary study endpoints were to assess the acute and late effects of radiation toxicity, according to the EORTC/ RTOG scale, as well as the therapeutic impact of this schedule in terms of local recurrence. RESULTS: The median follow up was 36 months. At the end of radiotherapy, grade I, II and III acute toxicity was observed in 34, 9 and4 patients, respectively. Late grade I and II toxicity was observed in 25 and in 8 patients respectively. Only two local recurrences were observed, 15 and 24 months post 3DCRT respectively. CONCLUSIONS: Our radiotherapy schedule achieves a high locoregional control rate with the advantage of voice preservation. The proposed hypofractionated schedule can be recommended as a standard radiotherapy treatment, since these results are comparable with those of conventional fractionation schedules. Versita, Warsaw 2013-05-21 /pmc/articles/PMC3691085/ /pubmed/23801916 http://dx.doi.org/10.2478/raon-2013-0020 Text en Copyright © by Association of Radiology & Oncology http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Research Article
Kouloulias, Vassilis E.
Zygogianni, Anna
Mosa, Eftychia
Platoni, Kalliopi
Georgakopoulos, John
Antypas, Christos
Beli, Ivelina
Tolia, Maria
Maragoudakis, Paulos
Giotakis, Ioannis
Papas, Zisis
Psyrri, Amanda
Kelekis, Nikolaos
Kouvaris, John
Evaluation of acute/late toxicity and local recurrence in T1–T2 glottic carcinoma treated with accelerated hypofractionated 3D-conformal external beam radiotherapy (3D-CRT)
title Evaluation of acute/late toxicity and local recurrence in T1–T2 glottic carcinoma treated with accelerated hypofractionated 3D-conformal external beam radiotherapy (3D-CRT)
title_full Evaluation of acute/late toxicity and local recurrence in T1–T2 glottic carcinoma treated with accelerated hypofractionated 3D-conformal external beam radiotherapy (3D-CRT)
title_fullStr Evaluation of acute/late toxicity and local recurrence in T1–T2 glottic carcinoma treated with accelerated hypofractionated 3D-conformal external beam radiotherapy (3D-CRT)
title_full_unstemmed Evaluation of acute/late toxicity and local recurrence in T1–T2 glottic carcinoma treated with accelerated hypofractionated 3D-conformal external beam radiotherapy (3D-CRT)
title_short Evaluation of acute/late toxicity and local recurrence in T1–T2 glottic carcinoma treated with accelerated hypofractionated 3D-conformal external beam radiotherapy (3D-CRT)
title_sort evaluation of acute/late toxicity and local recurrence in t1–t2 glottic carcinoma treated with accelerated hypofractionated 3d-conformal external beam radiotherapy (3d-crt)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691085/
https://www.ncbi.nlm.nih.gov/pubmed/23801916
http://dx.doi.org/10.2478/raon-2013-0020
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