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PLCE1 Polymorphism and Upper Gastrointestinal Cancer Risk: A Meta-Analysis

BACKGROUND: In recent years, the PLCE1 rs2274223 polymorphism has been extensively investigated as a potential risk factor for upper gastrointestinal cancers, including squamous cell carcinoma (ESCC) and gastric cancer. However, the results of these studies have been inconsistent. METHODS: A meta-an...

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Autores principales: Hao, Ning-Bo, He, Ya-Fei, Zhang, Dan, Luo, Gang, Chen, Bai-Jun, Zhang, Yao, Yang, Shi-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691110/
https://www.ncbi.nlm.nih.gov/pubmed/23826241
http://dx.doi.org/10.1371/journal.pone.0067229
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author Hao, Ning-Bo
He, Ya-Fei
Zhang, Dan
Luo, Gang
Chen, Bai-Jun
Zhang, Yao
Yang, Shi-Ming
author_facet Hao, Ning-Bo
He, Ya-Fei
Zhang, Dan
Luo, Gang
Chen, Bai-Jun
Zhang, Yao
Yang, Shi-Ming
author_sort Hao, Ning-Bo
collection PubMed
description BACKGROUND: In recent years, the PLCE1 rs2274223 polymorphism has been extensively investigated as a potential risk factor for upper gastrointestinal cancers, including squamous cell carcinoma (ESCC) and gastric cancer. However, the results of these studies have been inconsistent. METHODS: A meta-analysis of 13 case-control studies was performed including more than 11,000 subjects with genotyped PLCE1 rs2274223 polymorphisms. Odds ratios (OR) with 95% confidence intervals (CI) were employed to assess the association of the PLCE1 rs2274223 polymorphism with a susceptibility to ESCC or gastric cancer. RESULTS: A statistically significant increase in the risk of ESCC was associated with the PLCE1 rs2274223 polymorphism. This included the homozygous genetic model (OR = 1.46), heterozygous genetic model (OR = 1.25) and allelic genetic model (OR = 1.23). Similar results were consistently found for gastric cancer. In a subgroup analysis, the PLCE1 rs2274223 polymorphism was found to be a very sensitive marker for gastric cardia cancer as shown by the homozygous genetic model (OR = 2.23), heterozygous genetic model(OR = 1.59) and allelic genetic model (OR = 1.47). The risk associations of all of the gastric cardia cancer models were statistically significant. In contrast, none of the genetic models for non-cardia gastric cancer were significant. CONCLUSIONS: In this meta-analysis, the PLCE1 rs2274223 polymorphism was confirmed to have a statistically significant association with an increasing risk of ESCC and gastric cancer. The increase risk was especially observed for gastric cardia cancer.
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spelling pubmed-36911102013-07-03 PLCE1 Polymorphism and Upper Gastrointestinal Cancer Risk: A Meta-Analysis Hao, Ning-Bo He, Ya-Fei Zhang, Dan Luo, Gang Chen, Bai-Jun Zhang, Yao Yang, Shi-Ming PLoS One Research Article BACKGROUND: In recent years, the PLCE1 rs2274223 polymorphism has been extensively investigated as a potential risk factor for upper gastrointestinal cancers, including squamous cell carcinoma (ESCC) and gastric cancer. However, the results of these studies have been inconsistent. METHODS: A meta-analysis of 13 case-control studies was performed including more than 11,000 subjects with genotyped PLCE1 rs2274223 polymorphisms. Odds ratios (OR) with 95% confidence intervals (CI) were employed to assess the association of the PLCE1 rs2274223 polymorphism with a susceptibility to ESCC or gastric cancer. RESULTS: A statistically significant increase in the risk of ESCC was associated with the PLCE1 rs2274223 polymorphism. This included the homozygous genetic model (OR = 1.46), heterozygous genetic model (OR = 1.25) and allelic genetic model (OR = 1.23). Similar results were consistently found for gastric cancer. In a subgroup analysis, the PLCE1 rs2274223 polymorphism was found to be a very sensitive marker for gastric cardia cancer as shown by the homozygous genetic model (OR = 2.23), heterozygous genetic model(OR = 1.59) and allelic genetic model (OR = 1.47). The risk associations of all of the gastric cardia cancer models were statistically significant. In contrast, none of the genetic models for non-cardia gastric cancer were significant. CONCLUSIONS: In this meta-analysis, the PLCE1 rs2274223 polymorphism was confirmed to have a statistically significant association with an increasing risk of ESCC and gastric cancer. The increase risk was especially observed for gastric cardia cancer. Public Library of Science 2013-06-24 /pmc/articles/PMC3691110/ /pubmed/23826241 http://dx.doi.org/10.1371/journal.pone.0067229 Text en © 2013 Hao et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hao, Ning-Bo
He, Ya-Fei
Zhang, Dan
Luo, Gang
Chen, Bai-Jun
Zhang, Yao
Yang, Shi-Ming
PLCE1 Polymorphism and Upper Gastrointestinal Cancer Risk: A Meta-Analysis
title PLCE1 Polymorphism and Upper Gastrointestinal Cancer Risk: A Meta-Analysis
title_full PLCE1 Polymorphism and Upper Gastrointestinal Cancer Risk: A Meta-Analysis
title_fullStr PLCE1 Polymorphism and Upper Gastrointestinal Cancer Risk: A Meta-Analysis
title_full_unstemmed PLCE1 Polymorphism and Upper Gastrointestinal Cancer Risk: A Meta-Analysis
title_short PLCE1 Polymorphism and Upper Gastrointestinal Cancer Risk: A Meta-Analysis
title_sort plce1 polymorphism and upper gastrointestinal cancer risk: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691110/
https://www.ncbi.nlm.nih.gov/pubmed/23826241
http://dx.doi.org/10.1371/journal.pone.0067229
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