Deletion of the Fission Yeast Homologue of Human Insulinase Reveals a TORC1-Dependent Pathway Mediating Resistance to Proteotoxic Stress

Insulin Degrading Enzyme (IDE) is a protease conserved through evolution with a role in diabetes and Alzheimer's disease. The reason underlying its ubiquitous expression including cells lacking identified IDE substrates remains unknown. Here we show that the fission yeast IDE homologue (Iph1) m...

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Detalles Bibliográficos
Autores principales: Beuzelin, Clémentine, Evnouchidou, Irini, Rigolet, Pascal, Cauvet-Burgevin, Anne, Girard, Pierre-Marie, Dardalhon, Delphine, Culina, Slobodan, Gdoura, Abdelaziz, van Endert, Peter, Francesconi, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691139/
https://www.ncbi.nlm.nih.gov/pubmed/23826334
http://dx.doi.org/10.1371/journal.pone.0067705

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