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Addition of Rapamycin to Anti-CD3 Antibody Improves Long-Term Glycaemia Control in Diabetic NOD Mice

AIMS/HYPOTHESIS: Non-Fc-binding Anti CD3 antibody has proven successful in reverting diabetes in the non-obese diabetes mouse model of type 1 diabetes and limited efficacy has been observed in human clinical trials. We hypothesized that addition of rapamycin, an mTOR inhibitor capable of inducing op...

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Detalles Bibliográficos
Autores principales:	Perl, Shira, Perlman, Jordan, Weitzel, R. P., Phang, Oswald, Hsieh, Matthew M., Tisdale, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691209/ https://www.ncbi.nlm.nih.gov/pubmed/23826229 http://dx.doi.org/10.1371/journal.pone.0067189

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