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K(Ca)3.1 Channel-Blockade Attenuates Airway Pathophysiology in a Sheep Model of Chronic Asthma

BACKGROUND: The Ca(2+)-activated K(+) channel K(Ca)3.1 is expressed in several structural and inflammatory airway cell types and is proposed to play an important role in the pathophysiology of asthma. The aim of the current study was to determine whether inhibition of K(Ca)3.1 modifies experimental...

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Detalles Bibliográficos
Autores principales:	Van Der Velden, Joanne, Sum, Grace, Barker, Donna, Koumoundouros, Emmanuel, Barcham, Garry, Wulff, Heike, Castle, Neil, Bradding, Peter, Snibson, Kenneth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691218/ https://www.ncbi.nlm.nih.gov/pubmed/23826167 http://dx.doi.org/10.1371/journal.pone.0066886

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