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Mutations in Mll2, an H3K4 Methyltransferase, Result in Insulin Resistance and Impaired Glucose Tolerance in Mice
We employed a random mutagenesis approach to identify novel monogenic determinants of type 2 diabetes. Here we show that haplo-insufficiency of the histone methyltransferase myeloid-lineage leukemia (Mll2/Wbp7) gene causes type 2 diabetes in the mouse. We have shown that mice heterozygous for two se...
Autores principales: | Goldsworthy, Michelle, Absalom, Nathan L., Schröter, David, Matthews, Helen C., Bogani, Debora, Moir, Lee, Long, Anna, Church, Christopher, Hugill, Alison, Anstee, Quentin M., Goldin, Rob, Thursz, Mark, Hollfelder, Florian, Cox, Roger D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691224/ https://www.ncbi.nlm.nih.gov/pubmed/23826075 http://dx.doi.org/10.1371/journal.pone.0061870 |
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