Application of Multiplexed Kinase Inhibitor Beads to Study Kinome Adaptations in Drug-Resistant Leukemia

Protein kinases play key roles in oncogenic signaling and are a major focus in the development of targeted cancer therapies. Imatinib, a BCR-Abl tyrosine kinase inhibitor, is a successful front-line treatment for chronic myelogenous leukemia (CML). However, resistance to imatinib may be acquired by...

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Detalles Bibliográficos
Autores principales: Cooper, Matthew J., Cox, Nathan J., Zimmerman, Eric I., Dewar, Brian J., Duncan, James S., Whittle, Martin C., Nguyen, Thien A., Jones, Lauren S., Ghose Roy, Sreerupa, Smalley, David M., Kuan, Pei Fen, Richards, Kristy L., Christopherson, Richard I., Jin, Jian, Frye, Stephen V., Johnson, Gary L., Baldwin, Albert S., Graves, Lee M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691232/
https://www.ncbi.nlm.nih.gov/pubmed/23826126
http://dx.doi.org/10.1371/journal.pone.0066755

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