Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy

We report the discovery of a novel dual inhibitor targeting fungal sterol 14α-demethylase (CYP51 or Erg11) and human 5-lipoxygenase (5-LOX) with improved potency against 5-LOX due to its reduction of the iron center by its phenylenediamine core. A series of potent 5-LOX inhibitors containing a pheny...

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Detalles Bibliográficos
Autores principales: Hoobler, Eric K., Rai, Ganesha, Warrilow, Andrew G. S., Perry, Steven C., Smyrniotis, Christopher J., Jadhav, Ajit, Simeonov, Anton, Parker, Josie E., Kelly, Diane E., Maloney, David J., Kelly, S. L., Holman, Theodore R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691235/
https://www.ncbi.nlm.nih.gov/pubmed/23826084
http://dx.doi.org/10.1371/journal.pone.0065928

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