Hedgehog and Gli Signaling in Embryonic Mammary Gland Development

The first mouse mutation associated with a heritable defect in embryonic mammary gland development was Extratoes. It represents a functional null-mutation of the gene encoding Gli3, which is best known as a transcription factor mediating canonical Hedgehog (Hh) signaling. Here we review the roles of...

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Detalles Bibliográficos
Autores principales: Lee, May Yin, Sun, Li, Veltmaat, Jacqueline M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691482/
https://www.ncbi.nlm.nih.gov/pubmed/23677624
http://dx.doi.org/10.1007/s10911-013-9291-7
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author Lee, May Yin
Sun, Li
Veltmaat, Jacqueline M.
author_facet Lee, May Yin
Sun, Li
Veltmaat, Jacqueline M.
author_sort Lee, May Yin
collection PubMed
description The first mouse mutation associated with a heritable defect in embryonic mammary gland development was Extratoes. It represents a functional null-mutation of the gene encoding Gli3, which is best known as a transcription factor mediating canonical Hedgehog (Hh) signaling. Here we review the roles of Hh and Gli proteins in murine embryonic mammary development. We propose that an off-state for Hh signaling, mediated by Gli3-repressor, is determinant for induction of a mammary instead of hair follicle fate in the trunk surface ectoderm.
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spelling pubmed-36914822013-06-25 Hedgehog and Gli Signaling in Embryonic Mammary Gland Development Lee, May Yin Sun, Li Veltmaat, Jacqueline M. J Mammary Gland Biol Neoplasia Article The first mouse mutation associated with a heritable defect in embryonic mammary gland development was Extratoes. It represents a functional null-mutation of the gene encoding Gli3, which is best known as a transcription factor mediating canonical Hedgehog (Hh) signaling. Here we review the roles of Hh and Gli proteins in murine embryonic mammary development. We propose that an off-state for Hh signaling, mediated by Gli3-repressor, is determinant for induction of a mammary instead of hair follicle fate in the trunk surface ectoderm. Springer US 2013-05-16 2013 /pmc/articles/PMC3691482/ /pubmed/23677624 http://dx.doi.org/10.1007/s10911-013-9291-7 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Article
Lee, May Yin
Sun, Li
Veltmaat, Jacqueline M.
Hedgehog and Gli Signaling in Embryonic Mammary Gland Development
title Hedgehog and Gli Signaling in Embryonic Mammary Gland Development
title_full Hedgehog and Gli Signaling in Embryonic Mammary Gland Development
title_fullStr Hedgehog and Gli Signaling in Embryonic Mammary Gland Development
title_full_unstemmed Hedgehog and Gli Signaling in Embryonic Mammary Gland Development
title_short Hedgehog and Gli Signaling in Embryonic Mammary Gland Development
title_sort hedgehog and gli signaling in embryonic mammary gland development
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691482/
https://www.ncbi.nlm.nih.gov/pubmed/23677624
http://dx.doi.org/10.1007/s10911-013-9291-7
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