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Incorporating phylogenetic-based covarying mutations into RNAalifold for RNA consensus structure prediction

BACKGROUND: RNAalifold, a popular computational method for RNA consensus structure prediction, incorporates covarying mutations into a thermodynamic model to fold the aligned RNA sequences. When quantifying covariance, it evaluates conserved signals of two aligned columns with base-pairing rules. Th...

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Detalles Bibliográficos
Autores principales: Ge, Ping, Zhang, Shaojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691524/
https://www.ncbi.nlm.nih.gov/pubmed/23621982
http://dx.doi.org/10.1186/1471-2105-14-142