TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

BACKGROUND: A rare variant in the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) gene has been reported to be a genetic risk factor for Alzheimer’s disease by two independent groups (Odds ratio between 2.9-4.5). Given the key role of TREM2 in the effective phagocytosis of apoptotic neurona...

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Detalles Bibliográficos
Autores principales: Rayaprolu, Sruti, Mullen, Bianca, Baker, Matt, Lynch, Timothy, Finger, Elizabeth, Seeley, William W, Hatanpaa, Kimmo J, Lomen-Hoerth, Catherine, Kertesz, Andrew, Bigio, Eileen H, Lippa, Carol, Josephs, Keith A, Knopman, David S, White, Charles L, Caselli, Richard, Mackenzie, Ian R, Miller, Bruce L, Boczarska-Jedynak, Magdalena, Opala, Grzegorz, Krygowska-Wajs, Anna, Barcikowska, Maria, Younkin, Steven G, Petersen, Ronald C, Ertekin-Taner, Nilüfer, Uitti, Ryan J, Meschia, James F, Boylan, Kevin B, Boeve, Bradley F, Graff-Radford, Neill R, Wszolek, Zbigniew K, Dickson, Dennis W, Rademakers, Rosa, Ross, Owen A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691612/
https://www.ncbi.nlm.nih.gov/pubmed/23800361
http://dx.doi.org/10.1186/1750-1326-8-19

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