Cargando…

Exploiting the Unique ATP-Binding Pocket of Toxoplasma Calcium-Dependent Protein Kinase 1 To Identify Its Substrates

[Image: see text] Apicomplexan parasites rely on calcium as a second messenger to regulate a variety of essential cellular processes. Calcium-dependent protein kinases (CDPK), which transduce these signals, are conserved among apicomplexans but absent from mammalian hosts, making them attractive tar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lourido, Sebastian, Jeschke, Grace R., Turk, Benjamin E., Sibley, L. David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2013
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691715/ https://www.ncbi.nlm.nih.gov/pubmed/23530747 http://dx.doi.org/10.1021/cb400115y

Ejemplares similares

Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma
por: Lourido, Sebastian, et al.
Publicado: (2010)

SPARK regulates AGC kinases central to the Toxoplasma gondii asexual cycle
por: Herneisen, Alice L., et al.
Publicado: (2023)

Imatinib disassembles the regulatory core of Abelson kinase by binding to its ATP site and not by binding to its myristoyl pocket
por: Grzesiek, Stephan, et al.
Publicado: (2022)

Toxoplasma gondii exploits the host ESCRT machinery for parasite uptake of host cytosolic proteins
por: Rivera-Cuevas, Yolanda, et al.
Publicado: (2021)

Artemisia herba-alba sesquiterpenes: in silico inhibition in the ATP-binding pocket
por: Mohamed, Tarik A., et al.
Publicado: (2023)

CRISPR-Mediated Transcriptional Repression in Toxoplasma gondii
por: Markus, Benedikt M., et al.
Publicado: (2021)

Identification of PNG kinase substrates uncovers interactions with the translational repressor TRAL in the oocyte-to-embryo transition
por: Hara, Masatoshi, et al.
Publicado: (2018)

Andrographolide binds to ATP-binding pocket of VEGFR2 to impede VEGFA-mediated tumor-angiogenesis
por: Kajal, Kirti, et al.
Publicado: (2019)

Identifying Kinase Substrates via a Heavy ATP Kinase Assay and Quantitative Mass Spectrometry
por: Müller, André C., et al.
Publicado: (2016)

Tyrosine Kinase Inhibitors Induce Down-Regulation of c-Kit by Targeting the ATP Pocket
por: D'allard, Diane, et al.
Publicado: (2013)

ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy
por: Olivieri, Cristina, et al.
Publicado: (2022)

Optimizing Systems for Cas9 Expression in Toxoplasma gondii
por: Markus, Benedikt M., et al.
Publicado: (2019)

Screening the Toxoplasma kinome with high-throughput tagging (HiT) identifies a regulator of invasion and egress
por: Smith, Tyler A., et al.
Publicado: (2022)

Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120
por: Allsopp, Rebecca C., et al.
Publicado: (2017)

Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands
por: Ferri, Elena, et al.
Publicado: (2020)

High-Resolution Mapping of Transcription Initiation in the Asexual Stages of Toxoplasma gondii
por: Markus, Benedikt M., et al.
Publicado: (2021)

Identification of cryptic subunits from an apicomplexan ATP synthase
por: Huet, Diego, et al.
Publicado: (2018)

A computational protocol to evaluate the effects of protein mutants in the kinase gatekeeper position on the binding of ATP substrate analogues
por: Romano, Valentina, et al.
Publicado: (2017)

Identification of a Master Regulator of Differentiation in Toxoplasma
por: Waldman, Benjamin S., et al.
Publicado: (2020)

Calcium-dependent protein kinases are potential targets for Toxoplasma gondii vaccine
por: Foroutan, Masoud, et al.
Publicado: (2018)

Targeting the non‐ATP‐binding pocket of the MAP kinase p38γ mediates a novel mechanism of cytotoxicity in cutaneous T‐cell lymphoma (CTCL)
por: Zhang, Xu Hannah, et al.
Publicado: (2021)

Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A
por: Olivieri, Cristina, et al.
Publicado: (2021)

Efficient Genome Engineering of Toxoplasma gondii Using CRISPR/Cas9
por: Sidik, Saima M., et al.
Publicado: (2014)

Toxoplasma bradyzoites exhibit physiological plasticity of calcium and energy stores controlling motility and egress
por: Fu, Yong, et al.
Publicado: (2021)

ATP-Binding Pocket-Targeted Suppression of Src and Syk by Luteolin Contributes to Its Anti-Inflammatory Action
por: Lee, Jeong-Oog, et al.
Publicado: (2015)

Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase
por: Koulouris, Chloe R., et al.
Publicado: (2022)

Alveolar proteins stabilize cortical microtubules in Toxoplasma gondii
por: Harding, Clare R., et al.
Publicado: (2019)

A Unique Mode of Coenzyme A Binding to the Nucleotide Binding Pocket of Human Metastasis Suppressor NME1
por: Tossounian, Maria-Armineh, et al.
Publicado: (2023)

Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase
por: Shehata, Saifeldin N., et al.
Publicado: (2012)

Cryo-EM structure of the plant nitrate transporter AtCLCa reveals characteristics of the anion-binding site and the ATP-binding pocket
por: He, Jin, et al.
Publicado: (2022)

Genome-wide expression patterns of calcium-dependent protein kinases in Toxoplasma gondii
por: Wang, Jin-Lei, et al.
Publicado: (2015)

Characterization of a Toxoplasma gondii calcium calmodulin-dependent protein kinase homolog
por: Kato, Kentaro, et al.
Publicado: (2016)

Investigation of pyrophosphate versus ATP substrate selection in the Entamoeba histolytica acetate kinase
por: Dang, Thanh, et al.
Publicado: (2017)

Functional Classification of Super-Large Families of Enzymes Based on Substrate Binding Pocket Residues for Biocatalysis and Enzyme Engineering Applications
por: Sirota, Fernanda L., et al.
Publicado: (2021)

Pockets as structural descriptors of EGFR kinase conformations
por: Hasenahuer, Marcia Anahi, et al.
Publicado: (2017)

Selective substrate uptake: The role of ATP-binding cassette (ABC) importers in pathogenesis
por: Tanaka, Kari J., et al.
Publicado: (2017)

Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s
por: Yang, Jiao, et al.
Publicado: (2017)

Electrostatic Perturbations in the Substrate‐Binding Pocket of Taurine/α‐Ketoglutarate Dioxygenase Determine its Selectivity
por: Ali, Hafiz Saqib, et al.
Publicado: (2022)

Tracking the ATP-binding response in adenylate kinase in real time
por: Orädd, Fredrik, et al.
Publicado: (2021)

Author Correction: Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A
por: Olivieri, Cristina, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nfrlj7n790n7ikgdbh3u1pikuo