The Omega-3 Polyunsaturated Fatty Acid DHA Induces Simultaneous Apoptosis and Autophagy via Mitochondrial ROS-Mediated Akt-mTOR Signaling in Prostate Cancer Cells Expressing Mutant p53

Docosahexaenoic acid (DHA) induces autophagy-associated apoptotic cell death in wild-type p53 cancer cells via regulation of p53. The present study investigated the effects of DHA on PC3 and DU145 prostate cancer cell lines harboring mutant p53. Results show that, in addition to apoptosis, DHA incre...

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Detalles Bibliográficos
Autores principales: Shin, Soyeon, Jing, Kaipeng, Jeong, Soyeon, Kim, Nayeong, Song, Kyoung-Sub, Heo, Jun-Young, Park, Ji-Hoon, Seo, Kang-Sik, Han, Jeongsu, Park, Jong-Il, Kweon, Gi-Ryang, Park, Seung-Kiel, Wu, Tong, Hwang, Byung-Doo, Lim, Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691929/
https://www.ncbi.nlm.nih.gov/pubmed/23841076
http://dx.doi.org/10.1155/2013/568671

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