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The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease
In Parkinson’s disease, rapid eye movement sleep behaviour disorder is an early non-dopaminergic syndrome with nocturnal violence and increased muscle tone during rapid eye movement sleep that can precede Parkinsonism by several years. The neuronal origin of rapid eye movement sleep behaviour disord...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692035/ https://www.ncbi.nlm.nih.gov/pubmed/23801736 http://dx.doi.org/10.1093/brain/awt152 |
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author | García-Lorenzo, Daniel Longo-Dos Santos, Clarisse Ewenczyk, Claire Leu-Semenescu, Smaranda Gallea, Cecile Quattrocchi, Graziella Pita Lobo, Patricia Poupon, Cyril Benali, Habib Arnulf, Isabelle Vidailhet, Marie Lehericy, Stéphane |
author_facet | García-Lorenzo, Daniel Longo-Dos Santos, Clarisse Ewenczyk, Claire Leu-Semenescu, Smaranda Gallea, Cecile Quattrocchi, Graziella Pita Lobo, Patricia Poupon, Cyril Benali, Habib Arnulf, Isabelle Vidailhet, Marie Lehericy, Stéphane |
author_sort | García-Lorenzo, Daniel |
collection | PubMed |
description | In Parkinson’s disease, rapid eye movement sleep behaviour disorder is an early non-dopaminergic syndrome with nocturnal violence and increased muscle tone during rapid eye movement sleep that can precede Parkinsonism by several years. The neuronal origin of rapid eye movement sleep behaviour disorder in Parkinson’s disease is not precisely known; however, the locus subcoeruleus in the brainstem has been implicated as this structure blocks muscle tone during normal rapid eye movement sleep in animal models and can be damaged in Parkinson’s disease. Here, we studied the integrity of the locus coeruleus/subcoeruleus complex in patients with Parkinson’s disease using combined neuromelanin-sensitive, structural and diffusion magnetic resonance imaging approaches. We compared 24 patients with Parkinson’s disease and rapid eye movement sleep behaviour disorder, 12 patients without rapid eye movement sleep behaviour disorder and 19 age- and gender-matched healthy volunteers. All subjects underwent clinical examination and characterization of rapid eye movement sleep using video-polysomnography and multimodal imaging at 3 T. Using neuromelanin-sensitive imaging, reduced signal intensity was evident in the locus coeruleus/subcoeruleus area in patients with Parkinson’s disease that was more marked in patients with than those without rapid eye movement sleep behaviour disorder. Reduced signal intensity correlated with the percentage of abnormally increased muscle tone during rapid eye movement sleep. The results confirmed that this complex is affected in Parkinson’s disease and showed a gradual relationship between damage to this structure, presumably the locus subcoeruleus, and abnormal muscle tone during rapid eye movement sleep, which is the cardinal marker of rapid eye movement sleep behaviour disorder. In longitudinal studies, the technique may also provide early markers of non-dopaminergic Parkinson’s disease pathology to predict the occurrence of Parkinson’s disease. |
format | Online Article Text |
id | pubmed-3692035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-36920352013-06-25 The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease García-Lorenzo, Daniel Longo-Dos Santos, Clarisse Ewenczyk, Claire Leu-Semenescu, Smaranda Gallea, Cecile Quattrocchi, Graziella Pita Lobo, Patricia Poupon, Cyril Benali, Habib Arnulf, Isabelle Vidailhet, Marie Lehericy, Stéphane Brain Original Articles In Parkinson’s disease, rapid eye movement sleep behaviour disorder is an early non-dopaminergic syndrome with nocturnal violence and increased muscle tone during rapid eye movement sleep that can precede Parkinsonism by several years. The neuronal origin of rapid eye movement sleep behaviour disorder in Parkinson’s disease is not precisely known; however, the locus subcoeruleus in the brainstem has been implicated as this structure blocks muscle tone during normal rapid eye movement sleep in animal models and can be damaged in Parkinson’s disease. Here, we studied the integrity of the locus coeruleus/subcoeruleus complex in patients with Parkinson’s disease using combined neuromelanin-sensitive, structural and diffusion magnetic resonance imaging approaches. We compared 24 patients with Parkinson’s disease and rapid eye movement sleep behaviour disorder, 12 patients without rapid eye movement sleep behaviour disorder and 19 age- and gender-matched healthy volunteers. All subjects underwent clinical examination and characterization of rapid eye movement sleep using video-polysomnography and multimodal imaging at 3 T. Using neuromelanin-sensitive imaging, reduced signal intensity was evident in the locus coeruleus/subcoeruleus area in patients with Parkinson’s disease that was more marked in patients with than those without rapid eye movement sleep behaviour disorder. Reduced signal intensity correlated with the percentage of abnormally increased muscle tone during rapid eye movement sleep. The results confirmed that this complex is affected in Parkinson’s disease and showed a gradual relationship between damage to this structure, presumably the locus subcoeruleus, and abnormal muscle tone during rapid eye movement sleep, which is the cardinal marker of rapid eye movement sleep behaviour disorder. In longitudinal studies, the technique may also provide early markers of non-dopaminergic Parkinson’s disease pathology to predict the occurrence of Parkinson’s disease. Oxford University Press 2013-07 2013-06-22 /pmc/articles/PMC3692035/ /pubmed/23801736 http://dx.doi.org/10.1093/brain/awt152 Text en © The Author (2013). Published by Oxford University Press on behalf of the Guarantors of Brain. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Original Articles García-Lorenzo, Daniel Longo-Dos Santos, Clarisse Ewenczyk, Claire Leu-Semenescu, Smaranda Gallea, Cecile Quattrocchi, Graziella Pita Lobo, Patricia Poupon, Cyril Benali, Habib Arnulf, Isabelle Vidailhet, Marie Lehericy, Stéphane The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease |
title | The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease |
title_full | The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease |
title_fullStr | The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease |
title_full_unstemmed | The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease |
title_short | The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease |
title_sort | coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in parkinson’s disease |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692035/ https://www.ncbi.nlm.nih.gov/pubmed/23801736 http://dx.doi.org/10.1093/brain/awt152 |
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