Cargando…

The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease

In Parkinson’s disease, rapid eye movement sleep behaviour disorder is an early non-dopaminergic syndrome with nocturnal violence and increased muscle tone during rapid eye movement sleep that can precede Parkinsonism by several years. The neuronal origin of rapid eye movement sleep behaviour disord...

Descripción completa

Detalles Bibliográficos
Autores principales: García-Lorenzo, Daniel, Longo-Dos Santos, Clarisse, Ewenczyk, Claire, Leu-Semenescu, Smaranda, Gallea, Cecile, Quattrocchi, Graziella, Pita Lobo, Patricia, Poupon, Cyril, Benali, Habib, Arnulf, Isabelle, Vidailhet, Marie, Lehericy, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692035/
https://www.ncbi.nlm.nih.gov/pubmed/23801736
http://dx.doi.org/10.1093/brain/awt152
_version_ 1782274555608301568
author García-Lorenzo, Daniel
Longo-Dos Santos, Clarisse
Ewenczyk, Claire
Leu-Semenescu, Smaranda
Gallea, Cecile
Quattrocchi, Graziella
Pita Lobo, Patricia
Poupon, Cyril
Benali, Habib
Arnulf, Isabelle
Vidailhet, Marie
Lehericy, Stéphane
author_facet García-Lorenzo, Daniel
Longo-Dos Santos, Clarisse
Ewenczyk, Claire
Leu-Semenescu, Smaranda
Gallea, Cecile
Quattrocchi, Graziella
Pita Lobo, Patricia
Poupon, Cyril
Benali, Habib
Arnulf, Isabelle
Vidailhet, Marie
Lehericy, Stéphane
author_sort García-Lorenzo, Daniel
collection PubMed
description In Parkinson’s disease, rapid eye movement sleep behaviour disorder is an early non-dopaminergic syndrome with nocturnal violence and increased muscle tone during rapid eye movement sleep that can precede Parkinsonism by several years. The neuronal origin of rapid eye movement sleep behaviour disorder in Parkinson’s disease is not precisely known; however, the locus subcoeruleus in the brainstem has been implicated as this structure blocks muscle tone during normal rapid eye movement sleep in animal models and can be damaged in Parkinson’s disease. Here, we studied the integrity of the locus coeruleus/subcoeruleus complex in patients with Parkinson’s disease using combined neuromelanin-sensitive, structural and diffusion magnetic resonance imaging approaches. We compared 24 patients with Parkinson’s disease and rapid eye movement sleep behaviour disorder, 12 patients without rapid eye movement sleep behaviour disorder and 19 age- and gender-matched healthy volunteers. All subjects underwent clinical examination and characterization of rapid eye movement sleep using video-polysomnography and multimodal imaging at 3 T. Using neuromelanin-sensitive imaging, reduced signal intensity was evident in the locus coeruleus/subcoeruleus area in patients with Parkinson’s disease that was more marked in patients with than those without rapid eye movement sleep behaviour disorder. Reduced signal intensity correlated with the percentage of abnormally increased muscle tone during rapid eye movement sleep. The results confirmed that this complex is affected in Parkinson’s disease and showed a gradual relationship between damage to this structure, presumably the locus subcoeruleus, and abnormal muscle tone during rapid eye movement sleep, which is the cardinal marker of rapid eye movement sleep behaviour disorder. In longitudinal studies, the technique may also provide early markers of non-dopaminergic Parkinson’s disease pathology to predict the occurrence of Parkinson’s disease.
format Online
Article
Text
id pubmed-3692035
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-36920352013-06-25 The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease García-Lorenzo, Daniel Longo-Dos Santos, Clarisse Ewenczyk, Claire Leu-Semenescu, Smaranda Gallea, Cecile Quattrocchi, Graziella Pita Lobo, Patricia Poupon, Cyril Benali, Habib Arnulf, Isabelle Vidailhet, Marie Lehericy, Stéphane Brain Original Articles In Parkinson’s disease, rapid eye movement sleep behaviour disorder is an early non-dopaminergic syndrome with nocturnal violence and increased muscle tone during rapid eye movement sleep that can precede Parkinsonism by several years. The neuronal origin of rapid eye movement sleep behaviour disorder in Parkinson’s disease is not precisely known; however, the locus subcoeruleus in the brainstem has been implicated as this structure blocks muscle tone during normal rapid eye movement sleep in animal models and can be damaged in Parkinson’s disease. Here, we studied the integrity of the locus coeruleus/subcoeruleus complex in patients with Parkinson’s disease using combined neuromelanin-sensitive, structural and diffusion magnetic resonance imaging approaches. We compared 24 patients with Parkinson’s disease and rapid eye movement sleep behaviour disorder, 12 patients without rapid eye movement sleep behaviour disorder and 19 age- and gender-matched healthy volunteers. All subjects underwent clinical examination and characterization of rapid eye movement sleep using video-polysomnography and multimodal imaging at 3 T. Using neuromelanin-sensitive imaging, reduced signal intensity was evident in the locus coeruleus/subcoeruleus area in patients with Parkinson’s disease that was more marked in patients with than those without rapid eye movement sleep behaviour disorder. Reduced signal intensity correlated with the percentage of abnormally increased muscle tone during rapid eye movement sleep. The results confirmed that this complex is affected in Parkinson’s disease and showed a gradual relationship between damage to this structure, presumably the locus subcoeruleus, and abnormal muscle tone during rapid eye movement sleep, which is the cardinal marker of rapid eye movement sleep behaviour disorder. In longitudinal studies, the technique may also provide early markers of non-dopaminergic Parkinson’s disease pathology to predict the occurrence of Parkinson’s disease. Oxford University Press 2013-07 2013-06-22 /pmc/articles/PMC3692035/ /pubmed/23801736 http://dx.doi.org/10.1093/brain/awt152 Text en © The Author (2013). Published by Oxford University Press on behalf of the Guarantors of Brain. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Articles
García-Lorenzo, Daniel
Longo-Dos Santos, Clarisse
Ewenczyk, Claire
Leu-Semenescu, Smaranda
Gallea, Cecile
Quattrocchi, Graziella
Pita Lobo, Patricia
Poupon, Cyril
Benali, Habib
Arnulf, Isabelle
Vidailhet, Marie
Lehericy, Stéphane
The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease
title The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease
title_full The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease
title_fullStr The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease
title_full_unstemmed The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease
title_short The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease
title_sort coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in parkinson’s disease
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692035/
https://www.ncbi.nlm.nih.gov/pubmed/23801736
http://dx.doi.org/10.1093/brain/awt152
work_keys_str_mv AT garcialorenzodaniel thecoeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT longodossantosclarisse thecoeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT ewenczykclaire thecoeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT leusemenescusmaranda thecoeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT galleacecile thecoeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT quattrocchigraziella thecoeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT pitalobopatricia thecoeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT pouponcyril thecoeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT benalihabib thecoeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT arnulfisabelle thecoeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT vidailhetmarie thecoeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT lehericystephane thecoeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT garcialorenzodaniel coeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT longodossantosclarisse coeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT ewenczykclaire coeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT leusemenescusmaranda coeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT galleacecile coeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT quattrocchigraziella coeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT pitalobopatricia coeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT pouponcyril coeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT benalihabib coeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT arnulfisabelle coeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT vidailhetmarie coeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease
AT lehericystephane coeruleussubcoeruleuscomplexinrapideyemovementsleepbehaviourdisordersinparkinsonsdisease