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EvoDesign: de novo protein design based on structural and evolutionary profiles
Protein design aims to identify new protein sequences of desirable structure and biological function. Most current de novo protein design methods rely on physics-based force fields to search for low free-energy states following Anfinsen’s thermodynamic hypothesis. A major obstacle of such approaches...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692067/ https://www.ncbi.nlm.nih.gov/pubmed/23671331 http://dx.doi.org/10.1093/nar/gkt384 |