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MISTIC: mutual information server to infer coevolution

MISTIC (mutual information server to infer coevolution) is a web server for graphical representation of the information contained within a MSA (multiple sequence alignment) and a complete analysis tool for Mutual Information networks in protein families. The server outputs a graphical visualization...

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Autores principales: Simonetti, Franco L., Teppa, Elin, Chernomoretz, Ariel, Nielsen, Morten, Marino Buslje, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692073/
https://www.ncbi.nlm.nih.gov/pubmed/23716641
http://dx.doi.org/10.1093/nar/gkt427
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author Simonetti, Franco L.
Teppa, Elin
Chernomoretz, Ariel
Nielsen, Morten
Marino Buslje, Cristina
author_facet Simonetti, Franco L.
Teppa, Elin
Chernomoretz, Ariel
Nielsen, Morten
Marino Buslje, Cristina
author_sort Simonetti, Franco L.
collection PubMed
description MISTIC (mutual information server to infer coevolution) is a web server for graphical representation of the information contained within a MSA (multiple sequence alignment) and a complete analysis tool for Mutual Information networks in protein families. The server outputs a graphical visualization of several information-related quantities using a circos representation. This provides an integrated view of the MSA in terms of (i) the mutual information (MI) between residue pairs, (ii) sequence conservation and (iii) the residue cumulative and proximity MI scores. Further, an interactive interface to explore and characterize the MI network is provided. Several tools are offered for selecting subsets of nodes from the network for visualization. Node coloring can be set to match different attributes, such as conservation, cumulative MI, proximity MI and secondary structure. Finally, a zip file containing all results can be downloaded. The server is available at http://mistic.leloir.org.ar. In summary, MISTIC allows for a comprehensive, compact, visually rich view of the information contained within an MSA in a manner unique to any other publicly available web server. In particular, the use of circos representation of MI networks and the visualization of the cumulative MI and proximity MI concepts is novel.
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spelling pubmed-36920732013-06-25 MISTIC: mutual information server to infer coevolution Simonetti, Franco L. Teppa, Elin Chernomoretz, Ariel Nielsen, Morten Marino Buslje, Cristina Nucleic Acids Res Articles MISTIC (mutual information server to infer coevolution) is a web server for graphical representation of the information contained within a MSA (multiple sequence alignment) and a complete analysis tool for Mutual Information networks in protein families. The server outputs a graphical visualization of several information-related quantities using a circos representation. This provides an integrated view of the MSA in terms of (i) the mutual information (MI) between residue pairs, (ii) sequence conservation and (iii) the residue cumulative and proximity MI scores. Further, an interactive interface to explore and characterize the MI network is provided. Several tools are offered for selecting subsets of nodes from the network for visualization. Node coloring can be set to match different attributes, such as conservation, cumulative MI, proximity MI and secondary structure. Finally, a zip file containing all results can be downloaded. The server is available at http://mistic.leloir.org.ar. In summary, MISTIC allows for a comprehensive, compact, visually rich view of the information contained within an MSA in a manner unique to any other publicly available web server. In particular, the use of circos representation of MI networks and the visualization of the cumulative MI and proximity MI concepts is novel. Oxford University Press 2013-07 2013-05-28 /pmc/articles/PMC3692073/ /pubmed/23716641 http://dx.doi.org/10.1093/nar/gkt427 Text en © The Author(s) 2013. Published by Oxford University Press. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Simonetti, Franco L.
Teppa, Elin
Chernomoretz, Ariel
Nielsen, Morten
Marino Buslje, Cristina
MISTIC: mutual information server to infer coevolution
title MISTIC: mutual information server to infer coevolution
title_full MISTIC: mutual information server to infer coevolution
title_fullStr MISTIC: mutual information server to infer coevolution
title_full_unstemmed MISTIC: mutual information server to infer coevolution
title_short MISTIC: mutual information server to infer coevolution
title_sort mistic: mutual information server to infer coevolution
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692073/
https://www.ncbi.nlm.nih.gov/pubmed/23716641
http://dx.doi.org/10.1093/nar/gkt427
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