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Oral leukoplakia: Transmission electron microscopic correlation with clinical types and light microscopy

BACKGROUND: Leukoplakia, is a precancerous lesion that is most commonly encountered in the oral cavity. The grade of dysplasia is presumed to be the most important indicator of malignant potential. There are many promising aspects in advanced methods for the evaluation of oral precancer and cancer....

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Autores principales: Tamgadge, Sandhya Avinash, Ganvir, Sindhu Milind, Hazarey, Vinay Krishnarao, Tamgadge, Avinash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692208/
https://www.ncbi.nlm.nih.gov/pubmed/23814570
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author Tamgadge, Sandhya Avinash
Ganvir, Sindhu Milind
Hazarey, Vinay Krishnarao
Tamgadge, Avinash
author_facet Tamgadge, Sandhya Avinash
Ganvir, Sindhu Milind
Hazarey, Vinay Krishnarao
Tamgadge, Avinash
author_sort Tamgadge, Sandhya Avinash
collection PubMed
description BACKGROUND: Leukoplakia, is a precancerous lesion that is most commonly encountered in the oral cavity. The grade of dysplasia is presumed to be the most important indicator of malignant potential. There are many promising aspects in advanced methods for the evaluation of oral precancer and cancer. Among these methods, electron microscopic examination predicts the true biologic potential more accurately than conventional histology and has some success in the early detection of potentially malignant lesions. It has been reported in the literature that there is some correlation between clinical, histopathological, and transmission electron microscopic features. MATERIALS AND METHODS: In this cohort study (prospective research), from the total of 9 subjects, 3 had homogenous leukoplakia, 3 had ulcerative type of oral leukoplakia, and 3 had nodular type of oral leukoplakia. Two patients were selected as control patients. Transmission electron microscopic examination was carried for all the cases and controls. All the findings were correlated with clinical features and light microscopy. RESULTS: Clinically and histologically, mild leukoplakia showed break in basement membrane, which can only be observed under transmission electron microscope (TEM). Additional dysplastic features were observed under transmission electron microscope, which are indicative of neoplastic process. CONCLUSIONS: Thus, it is finally concluded that nodular leukoplakia seems to be the most severe clinical type of leukoplakia showing highest risk of malignant transformation. Homogenous leukoplakia might show break in basement membrane under TEM.
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spelling pubmed-36922082013-06-28 Oral leukoplakia: Transmission electron microscopic correlation with clinical types and light microscopy Tamgadge, Sandhya Avinash Ganvir, Sindhu Milind Hazarey, Vinay Krishnarao Tamgadge, Avinash Dent Res J (Isfahan) Original Article BACKGROUND: Leukoplakia, is a precancerous lesion that is most commonly encountered in the oral cavity. The grade of dysplasia is presumed to be the most important indicator of malignant potential. There are many promising aspects in advanced methods for the evaluation of oral precancer and cancer. Among these methods, electron microscopic examination predicts the true biologic potential more accurately than conventional histology and has some success in the early detection of potentially malignant lesions. It has been reported in the literature that there is some correlation between clinical, histopathological, and transmission electron microscopic features. MATERIALS AND METHODS: In this cohort study (prospective research), from the total of 9 subjects, 3 had homogenous leukoplakia, 3 had ulcerative type of oral leukoplakia, and 3 had nodular type of oral leukoplakia. Two patients were selected as control patients. Transmission electron microscopic examination was carried for all the cases and controls. All the findings were correlated with clinical features and light microscopy. RESULTS: Clinically and histologically, mild leukoplakia showed break in basement membrane, which can only be observed under transmission electron microscope (TEM). Additional dysplastic features were observed under transmission electron microscope, which are indicative of neoplastic process. CONCLUSIONS: Thus, it is finally concluded that nodular leukoplakia seems to be the most severe clinical type of leukoplakia showing highest risk of malignant transformation. Homogenous leukoplakia might show break in basement membrane under TEM. Medknow Publications & Media Pvt Ltd 2012-12 /pmc/articles/PMC3692208/ /pubmed/23814570 Text en Copyright: © Dental Research Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Tamgadge, Sandhya Avinash
Ganvir, Sindhu Milind
Hazarey, Vinay Krishnarao
Tamgadge, Avinash
Oral leukoplakia: Transmission electron microscopic correlation with clinical types and light microscopy
title Oral leukoplakia: Transmission electron microscopic correlation with clinical types and light microscopy
title_full Oral leukoplakia: Transmission electron microscopic correlation with clinical types and light microscopy
title_fullStr Oral leukoplakia: Transmission electron microscopic correlation with clinical types and light microscopy
title_full_unstemmed Oral leukoplakia: Transmission electron microscopic correlation with clinical types and light microscopy
title_short Oral leukoplakia: Transmission electron microscopic correlation with clinical types and light microscopy
title_sort oral leukoplakia: transmission electron microscopic correlation with clinical types and light microscopy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692208/
https://www.ncbi.nlm.nih.gov/pubmed/23814570
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