PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control

All class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulatory subunits through interactions that have been thought to be constitutive. PI3Kγ is key to the regulation of immune cell responses activated by G protein-coupled receptors (GPCRs). Remarkably we find that PKCβ phosphoryla...

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Detalles Bibliográficos
Autores principales: Walser, Romy, Burke, John E., Gogvadze, Elena, Bohnacker, Thomas, Zhang, Xuxiao, Hess, Daniel, Küenzi, Peter, Leitges, Michael, Hirsch, Emilio, Williams, Roger L., Laffargue, Muriel, Wymann, Matthias P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692425/
https://www.ncbi.nlm.nih.gov/pubmed/23824069
http://dx.doi.org/10.1371/journal.pbio.1001587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692425/
https://www.ncbi.nlm.nih.gov/pubmed/23824069
http://dx.doi.org/10.1371/journal.pbio.1001587

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