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Characterization of N-terminally mutated cardiac Na(+) channels associated with long QT syndrome 3 and Brugada syndrome

Mutations in SCN5A, the gene encoding the cardiac voltage-gated Na(+) channel hNa(v)1.5, can result in life-threatening arrhythmias including long QT syndrome 3 (LQT3) and Brugada syndrome (BrS). Numerous mutant hNa(v)1.5 channels have been characterized upon heterologous expression and patch-clamp...

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Detalles Bibliográficos
Autores principales:	Gütter, Christian, Benndorf, Klaus, Zimmer, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693076/ https://www.ncbi.nlm.nih.gov/pubmed/23805106 http://dx.doi.org/10.3389/fphys.2013.00153

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