HSP90 Inhibitors, Geldanamycin and Radicicol, Enhance Fisetin-Induced Cytotoxicity via Induction of Apoptosis in Human Colonic Cancer Cells

We revealed the cytotoxic effect of the flavonoid, fisetin (FIS), on human COLO205 colon cancer cells in the presence and absence of the HSP90 inhibitors, geldanamycin (GA) and radicicol (RAD). Compared to FIS treatment alone of COLO205 cells, GA and RAD significantly enhanced FIS-induced cytotoxici...

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Detalles Bibliográficos
Autores principales: Wu, Ming-Shun, Lien, Gi-Shih, Shen, Shing-Chuan, Yang, Liang-Yo, Chen, Yen-Chou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693119/
https://www.ncbi.nlm.nih.gov/pubmed/23840275
http://dx.doi.org/10.1155/2013/987612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693119/
https://www.ncbi.nlm.nih.gov/pubmed/23840275
http://dx.doi.org/10.1155/2013/987612

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