Chloroquine Interference with Hemoglobin Endocytic Trafficking Suppresses Adaptive Heme and Iron Homeostasis in Macrophages: The Paradox of an Antimalarial Agent

The CD163 scavenger receptor pathway for Hb:Hp complexes is an essential mechanism of protection against the toxicity of extracellular hemoglobin (Hb), which can accumulate in the vasculature and within tissues during hemolysis. Chloroquine is a lysosomotropic agent, which has been extensively used...

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Detalles Bibliográficos
Autores principales: Schaer, Christian A., Laczko, Endre, Schoedon, Gabriele, Schaer, Dominik J., Vallelian, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693174/
https://www.ncbi.nlm.nih.gov/pubmed/23840921
http://dx.doi.org/10.1155/2013/870472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693174/
https://www.ncbi.nlm.nih.gov/pubmed/23840921
http://dx.doi.org/10.1155/2013/870472

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