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GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer
Genome wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC) with another two loci being close to genome-wide significance. We pooled data from a GWAS conducted in North America with another GWAS from the United Kingdom. We selected the top 24,5...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693183/ https://www.ncbi.nlm.nih.gov/pubmed/23535730 http://dx.doi.org/10.1038/ng.2564 |
| _version_ | 1782274717974003712 |
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| author | Pharoah, Paul D. P. Tsai, Ya-Yu Ramus, Susan J. Phelan, Catherine M. Goode, Ellen L. Lawrenson, Kate Price, Melissa Fridley, Brooke L. Tyrer, Jonathan P. Shen, Howard Weber, Rachel Karevan, Rod Larson, Melissa C. Song, Honglin Tessier, Daniel C. Bacot, François Vincent, Daniel Cunningham, Julie M. Dennis, Joe Dicks, Ed Aben, Katja K. Anton-Culver, Hoda Antonenkova, Natalia Armasu, Sebastian M. Baglietto, Laura Bandera, Elisa V. Beckmann, Matthias W. Birrer, Michael J. Bloom, Greg Bogdanova, Natalia Brenton, James D. Brinton, Louise A. Brooks-Wilson, Angela Brown, Robert Butzow, Ralf Campbell, Ian Carney, Michael E Carvalho, Renato S. Chang-Claude, Jenny Chen, Y. Anne Chen, Zhihua Chow, Wong-Ho Cicek, Mine S. Coetzee, Gerhard Cook, Linda S. Cramer, Daniel W. Cybulski, Cezary Dansonka-Mieszkowska, Agnieszka Despierre, Evelyn Doherty, Jennifer A Dörk, Thilo du Bois, Andreas Dürst, Matthias Eccles, Diana Edwards, Robert Ekici, Arif B. Fasching, Peter A. Fenstermacher, David Flanagan, James Gao, Yu-Tang Garcia-Closas, Montserrat Gentry-Maharaj, Aleksandra Giles, Graham Gjyshi, Anxhela Gore, Martin Gronwald, Jacek Guo, Qi Halle, Mari K Harter, Philipp Hein, Alexander Heitz, Florian Hillemanns, Peter Hoatlin, Maureen Høgdall, Estrid Høgdall, Claus K. Hosono, Satoyo Jakubowska, Anna Jensen, Allan Kalli, Kimberly R. Karlan, Beth Y. Kelemen, Linda E. Kiemeney, Lambertus A. Kjaer, Susanne Krüger Konecny, Gottfried E. Krakstad, Camilla Kupryjanczyk, Jolanta Lambrechts, Diether Lambrechts, Sandrina Le, Nhu D. Lee, Nathan Lee, Janet Leminen, Arto Lim, Boon Kiong Lissowska, Jolanta Lubiński, Jan Lundvall, Lene Lurie, Galina Massuger, Leon F.A.G. Matsuo, Keitaro McGuire, Valerie McLaughlin, John R Menon, Usha Modugno, Francesmary Moysich, Kirsten B. Nakanishi, Toru Narod, Steven A. Ness, Roberta B. Nevanlinna, Heli Nickels, Stefan Noushmehr, Houtan Odunsi, Kunle Olson, Sara Orlow, Irene Paul, James Pejovic, Tanja Pelttari, Liisa M Permuth-Wey, Jenny Pike, Malcolm C Poole, Elizabeth M Qu, Xiaotao Risch, Harvey A. Rodriguez-Rodriguez, Lorna Rossing, Mary Anne Rudolph, Anja Runnebaum, Ingo Rzepecka, Iwona K Salvesen, Helga B. Schwaab, Ira Severi, Gianluca Shen, Hui Shridhar, Vijayalakshmi Shu, Xiao-Ou Sieh, Weiva Southey, Melissa C. Spellman, Paul Tajima, Kazuo Teo, Soo-Hwang Terry, Kathryn L. Thompson, Pamela J Timorek, Agnieszka Tworoger, Shelley S. van Altena, Anne M. Berg, David Van Den Vergote, Ignace Vierkant, Robert A. Vitonis, Allison F. Wang-Gohrke, Shan Wentzensen, Nicolas Whittemore, Alice S. Wik, Elisabeth Winterhoff, Boris Woo, Yin Ling Wu, Anna H Yang, Hannah P. Zheng, Wei Ziogas, Argyrios Zulkifli, Famida Goodman, Marc T. Hall, Per Easton, Douglas F Pearce, Celeste L Berchuck, Andrew Chenevix-Trench, Georgia Iversen, Edwin Monteiro, Alvaro N.A. Gayther, Simon A. Schildkraut, Joellen M. Sellers, Thomas A. |
| author_facet | Pharoah, Paul D. P. Tsai, Ya-Yu Ramus, Susan J. Phelan, Catherine M. Goode, Ellen L. Lawrenson, Kate Price, Melissa Fridley, Brooke L. Tyrer, Jonathan P. Shen, Howard Weber, Rachel Karevan, Rod Larson, Melissa C. Song, Honglin Tessier, Daniel C. Bacot, François Vincent, Daniel Cunningham, Julie M. Dennis, Joe Dicks, Ed Aben, Katja K. Anton-Culver, Hoda Antonenkova, Natalia Armasu, Sebastian M. Baglietto, Laura Bandera, Elisa V. Beckmann, Matthias W. Birrer, Michael J. Bloom, Greg Bogdanova, Natalia Brenton, James D. Brinton, Louise A. Brooks-Wilson, Angela Brown, Robert Butzow, Ralf Campbell, Ian Carney, Michael E Carvalho, Renato S. Chang-Claude, Jenny Chen, Y. Anne Chen, Zhihua Chow, Wong-Ho Cicek, Mine S. Coetzee, Gerhard Cook, Linda S. Cramer, Daniel W. Cybulski, Cezary Dansonka-Mieszkowska, Agnieszka Despierre, Evelyn Doherty, Jennifer A Dörk, Thilo du Bois, Andreas Dürst, Matthias Eccles, Diana Edwards, Robert Ekici, Arif B. Fasching, Peter A. Fenstermacher, David Flanagan, James Gao, Yu-Tang Garcia-Closas, Montserrat Gentry-Maharaj, Aleksandra Giles, Graham Gjyshi, Anxhela Gore, Martin Gronwald, Jacek Guo, Qi Halle, Mari K Harter, Philipp Hein, Alexander Heitz, Florian Hillemanns, Peter Hoatlin, Maureen Høgdall, Estrid Høgdall, Claus K. Hosono, Satoyo Jakubowska, Anna Jensen, Allan Kalli, Kimberly R. Karlan, Beth Y. Kelemen, Linda E. Kiemeney, Lambertus A. Kjaer, Susanne Krüger Konecny, Gottfried E. Krakstad, Camilla Kupryjanczyk, Jolanta Lambrechts, Diether Lambrechts, Sandrina Le, Nhu D. Lee, Nathan Lee, Janet Leminen, Arto Lim, Boon Kiong Lissowska, Jolanta Lubiński, Jan Lundvall, Lene Lurie, Galina Massuger, Leon F.A.G. Matsuo, Keitaro McGuire, Valerie McLaughlin, John R Menon, Usha Modugno, Francesmary Moysich, Kirsten B. Nakanishi, Toru Narod, Steven A. Ness, Roberta B. Nevanlinna, Heli Nickels, Stefan Noushmehr, Houtan Odunsi, Kunle Olson, Sara Orlow, Irene Paul, James Pejovic, Tanja Pelttari, Liisa M Permuth-Wey, Jenny Pike, Malcolm C Poole, Elizabeth M Qu, Xiaotao Risch, Harvey A. Rodriguez-Rodriguez, Lorna Rossing, Mary Anne Rudolph, Anja Runnebaum, Ingo Rzepecka, Iwona K Salvesen, Helga B. Schwaab, Ira Severi, Gianluca Shen, Hui Shridhar, Vijayalakshmi Shu, Xiao-Ou Sieh, Weiva Southey, Melissa C. Spellman, Paul Tajima, Kazuo Teo, Soo-Hwang Terry, Kathryn L. Thompson, Pamela J Timorek, Agnieszka Tworoger, Shelley S. van Altena, Anne M. Berg, David Van Den Vergote, Ignace Vierkant, Robert A. Vitonis, Allison F. Wang-Gohrke, Shan Wentzensen, Nicolas Whittemore, Alice S. Wik, Elisabeth Winterhoff, Boris Woo, Yin Ling Wu, Anna H Yang, Hannah P. Zheng, Wei Ziogas, Argyrios Zulkifli, Famida Goodman, Marc T. Hall, Per Easton, Douglas F Pearce, Celeste L Berchuck, Andrew Chenevix-Trench, Georgia Iversen, Edwin Monteiro, Alvaro N.A. Gayther, Simon A. Schildkraut, Joellen M. Sellers, Thomas A. |
| author_sort | Pharoah, Paul D. P. |
| collection | PubMed |
| description | Genome wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC) with another two loci being close to genome-wide significance. We pooled data from a GWAS conducted in North America with another GWAS from the United Kingdom. We selected the top 24,551 SNPs for inclusion on the iCOGS custom genotyping array. Follow-up genotyping was carried out in 18,174 cases and 26,134 controls from 43 studies from the Ovarian Cancer Association Consortium. We validated the two loci at 3q25 and 17q21 previously near genome-wide significance and identified three novel loci associated with risk; two loci associated with all EOC subtypes, at 8q21 (rs11782652, P=5.5×10(-9)) and 10p12 (rs1243180; P=1.8×10(-8)), and another locus specific to the serous subtype at 17q12 (rs757210; P=8.1×10(-10)). An integrated molecular analysis of genes and regulatory regions at these loci provided evidence for functional mechanisms underlying susceptibility that implicates CHMP4C in the pathogenesis of ovarian cancer. |
| format | Online Article Text |
| id | pubmed-3693183 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-36931832013-10-01 GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer Pharoah, Paul D. P. Tsai, Ya-Yu Ramus, Susan J. Phelan, Catherine M. Goode, Ellen L. Lawrenson, Kate Price, Melissa Fridley, Brooke L. Tyrer, Jonathan P. Shen, Howard Weber, Rachel Karevan, Rod Larson, Melissa C. Song, Honglin Tessier, Daniel C. Bacot, François Vincent, Daniel Cunningham, Julie M. Dennis, Joe Dicks, Ed Aben, Katja K. Anton-Culver, Hoda Antonenkova, Natalia Armasu, Sebastian M. Baglietto, Laura Bandera, Elisa V. Beckmann, Matthias W. Birrer, Michael J. Bloom, Greg Bogdanova, Natalia Brenton, James D. Brinton, Louise A. Brooks-Wilson, Angela Brown, Robert Butzow, Ralf Campbell, Ian Carney, Michael E Carvalho, Renato S. Chang-Claude, Jenny Chen, Y. Anne Chen, Zhihua Chow, Wong-Ho Cicek, Mine S. Coetzee, Gerhard Cook, Linda S. Cramer, Daniel W. Cybulski, Cezary Dansonka-Mieszkowska, Agnieszka Despierre, Evelyn Doherty, Jennifer A Dörk, Thilo du Bois, Andreas Dürst, Matthias Eccles, Diana Edwards, Robert Ekici, Arif B. Fasching, Peter A. Fenstermacher, David Flanagan, James Gao, Yu-Tang Garcia-Closas, Montserrat Gentry-Maharaj, Aleksandra Giles, Graham Gjyshi, Anxhela Gore, Martin Gronwald, Jacek Guo, Qi Halle, Mari K Harter, Philipp Hein, Alexander Heitz, Florian Hillemanns, Peter Hoatlin, Maureen Høgdall, Estrid Høgdall, Claus K. Hosono, Satoyo Jakubowska, Anna Jensen, Allan Kalli, Kimberly R. Karlan, Beth Y. Kelemen, Linda E. Kiemeney, Lambertus A. Kjaer, Susanne Krüger Konecny, Gottfried E. Krakstad, Camilla Kupryjanczyk, Jolanta Lambrechts, Diether Lambrechts, Sandrina Le, Nhu D. Lee, Nathan Lee, Janet Leminen, Arto Lim, Boon Kiong Lissowska, Jolanta Lubiński, Jan Lundvall, Lene Lurie, Galina Massuger, Leon F.A.G. Matsuo, Keitaro McGuire, Valerie McLaughlin, John R Menon, Usha Modugno, Francesmary Moysich, Kirsten B. Nakanishi, Toru Narod, Steven A. Ness, Roberta B. Nevanlinna, Heli Nickels, Stefan Noushmehr, Houtan Odunsi, Kunle Olson, Sara Orlow, Irene Paul, James Pejovic, Tanja Pelttari, Liisa M Permuth-Wey, Jenny Pike, Malcolm C Poole, Elizabeth M Qu, Xiaotao Risch, Harvey A. Rodriguez-Rodriguez, Lorna Rossing, Mary Anne Rudolph, Anja Runnebaum, Ingo Rzepecka, Iwona K Salvesen, Helga B. Schwaab, Ira Severi, Gianluca Shen, Hui Shridhar, Vijayalakshmi Shu, Xiao-Ou Sieh, Weiva Southey, Melissa C. Spellman, Paul Tajima, Kazuo Teo, Soo-Hwang Terry, Kathryn L. Thompson, Pamela J Timorek, Agnieszka Tworoger, Shelley S. van Altena, Anne M. Berg, David Van Den Vergote, Ignace Vierkant, Robert A. Vitonis, Allison F. Wang-Gohrke, Shan Wentzensen, Nicolas Whittemore, Alice S. Wik, Elisabeth Winterhoff, Boris Woo, Yin Ling Wu, Anna H Yang, Hannah P. Zheng, Wei Ziogas, Argyrios Zulkifli, Famida Goodman, Marc T. Hall, Per Easton, Douglas F Pearce, Celeste L Berchuck, Andrew Chenevix-Trench, Georgia Iversen, Edwin Monteiro, Alvaro N.A. Gayther, Simon A. Schildkraut, Joellen M. Sellers, Thomas A. Nat Genet Article Genome wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC) with another two loci being close to genome-wide significance. We pooled data from a GWAS conducted in North America with another GWAS from the United Kingdom. We selected the top 24,551 SNPs for inclusion on the iCOGS custom genotyping array. Follow-up genotyping was carried out in 18,174 cases and 26,134 controls from 43 studies from the Ovarian Cancer Association Consortium. We validated the two loci at 3q25 and 17q21 previously near genome-wide significance and identified three novel loci associated with risk; two loci associated with all EOC subtypes, at 8q21 (rs11782652, P=5.5×10(-9)) and 10p12 (rs1243180; P=1.8×10(-8)), and another locus specific to the serous subtype at 17q12 (rs757210; P=8.1×10(-10)). An integrated molecular analysis of genes and regulatory regions at these loci provided evidence for functional mechanisms underlying susceptibility that implicates CHMP4C in the pathogenesis of ovarian cancer. 2013-04 /pmc/articles/PMC3693183/ /pubmed/23535730 http://dx.doi.org/10.1038/ng.2564 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Pharoah, Paul D. P. Tsai, Ya-Yu Ramus, Susan J. Phelan, Catherine M. Goode, Ellen L. Lawrenson, Kate Price, Melissa Fridley, Brooke L. Tyrer, Jonathan P. Shen, Howard Weber, Rachel Karevan, Rod Larson, Melissa C. Song, Honglin Tessier, Daniel C. Bacot, François Vincent, Daniel Cunningham, Julie M. Dennis, Joe Dicks, Ed Aben, Katja K. Anton-Culver, Hoda Antonenkova, Natalia Armasu, Sebastian M. Baglietto, Laura Bandera, Elisa V. Beckmann, Matthias W. Birrer, Michael J. Bloom, Greg Bogdanova, Natalia Brenton, James D. Brinton, Louise A. Brooks-Wilson, Angela Brown, Robert Butzow, Ralf Campbell, Ian Carney, Michael E Carvalho, Renato S. Chang-Claude, Jenny Chen, Y. Anne Chen, Zhihua Chow, Wong-Ho Cicek, Mine S. Coetzee, Gerhard Cook, Linda S. Cramer, Daniel W. Cybulski, Cezary Dansonka-Mieszkowska, Agnieszka Despierre, Evelyn Doherty, Jennifer A Dörk, Thilo du Bois, Andreas Dürst, Matthias Eccles, Diana Edwards, Robert Ekici, Arif B. Fasching, Peter A. Fenstermacher, David Flanagan, James Gao, Yu-Tang Garcia-Closas, Montserrat Gentry-Maharaj, Aleksandra Giles, Graham Gjyshi, Anxhela Gore, Martin Gronwald, Jacek Guo, Qi Halle, Mari K Harter, Philipp Hein, Alexander Heitz, Florian Hillemanns, Peter Hoatlin, Maureen Høgdall, Estrid Høgdall, Claus K. Hosono, Satoyo Jakubowska, Anna Jensen, Allan Kalli, Kimberly R. Karlan, Beth Y. Kelemen, Linda E. Kiemeney, Lambertus A. Kjaer, Susanne Krüger Konecny, Gottfried E. Krakstad, Camilla Kupryjanczyk, Jolanta Lambrechts, Diether Lambrechts, Sandrina Le, Nhu D. Lee, Nathan Lee, Janet Leminen, Arto Lim, Boon Kiong Lissowska, Jolanta Lubiński, Jan Lundvall, Lene Lurie, Galina Massuger, Leon F.A.G. Matsuo, Keitaro McGuire, Valerie McLaughlin, John R Menon, Usha Modugno, Francesmary Moysich, Kirsten B. Nakanishi, Toru Narod, Steven A. Ness, Roberta B. Nevanlinna, Heli Nickels, Stefan Noushmehr, Houtan Odunsi, Kunle Olson, Sara Orlow, Irene Paul, James Pejovic, Tanja Pelttari, Liisa M Permuth-Wey, Jenny Pike, Malcolm C Poole, Elizabeth M Qu, Xiaotao Risch, Harvey A. Rodriguez-Rodriguez, Lorna Rossing, Mary Anne Rudolph, Anja Runnebaum, Ingo Rzepecka, Iwona K Salvesen, Helga B. Schwaab, Ira Severi, Gianluca Shen, Hui Shridhar, Vijayalakshmi Shu, Xiao-Ou Sieh, Weiva Southey, Melissa C. Spellman, Paul Tajima, Kazuo Teo, Soo-Hwang Terry, Kathryn L. Thompson, Pamela J Timorek, Agnieszka Tworoger, Shelley S. van Altena, Anne M. Berg, David Van Den Vergote, Ignace Vierkant, Robert A. Vitonis, Allison F. Wang-Gohrke, Shan Wentzensen, Nicolas Whittemore, Alice S. Wik, Elisabeth Winterhoff, Boris Woo, Yin Ling Wu, Anna H Yang, Hannah P. Zheng, Wei Ziogas, Argyrios Zulkifli, Famida Goodman, Marc T. Hall, Per Easton, Douglas F Pearce, Celeste L Berchuck, Andrew Chenevix-Trench, Georgia Iversen, Edwin Monteiro, Alvaro N.A. Gayther, Simon A. Schildkraut, Joellen M. Sellers, Thomas A. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer |
| title | GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer |
| title_full | GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer |
| title_fullStr | GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer |
| title_full_unstemmed | GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer |
| title_short | GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer |
| title_sort | gwas meta-analysis and replication identifies three new susceptibility loci for ovarian cancer |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693183/ https://www.ncbi.nlm.nih.gov/pubmed/23535730 http://dx.doi.org/10.1038/ng.2564 |
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