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Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery
Several challenges are associated with current vaccine strategies, including repeated immunizations, poor patient compliance, and limited approved routes for delivery, which may hinder induction of protective immunity. Thus, there is a need for new vaccine adjuvants capable of multi-route administra...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693819/ https://www.ncbi.nlm.nih.gov/pubmed/23818778 http://dx.doi.org/10.2147/IJN.S45317 |
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author | Petersen, Latrisha K Huntimer, Lucas Walz, Katharine Ramer-Tait, Amanda Wannemuehler, Michael J Narasimhan, Balaji |
author_facet | Petersen, Latrisha K Huntimer, Lucas Walz, Katharine Ramer-Tait, Amanda Wannemuehler, Michael J Narasimhan, Balaji |
author_sort | Petersen, Latrisha K |
collection | PubMed |
description | Several challenges are associated with current vaccine strategies, including repeated immunizations, poor patient compliance, and limited approved routes for delivery, which may hinder induction of protective immunity. Thus, there is a need for new vaccine adjuvants capable of multi-route administration and prolonged antigen release at the site of administration by providing a depot within tissue. In this work, we designed a combinatorial platform to investigate the in vivo distribution, depot effect, and localized persistence of polyanhydride nanoparticles as a function of nanoparticle chemistry and administration route. Our observations indicated that the route of administration differentially affected tissue residence times. All nanoparticles rapidly dispersed when delivered intranasally but provided a depot when administered parenterally. When amphiphilic and hydrophobic nanoparticles were administered intranasally, they persisted within lung tissue. These results provide insights into the chemistry- and route-dependent distribution and tissue-specific association of polyanhydride nanoparticle-based vaccine adjuvants. |
format | Online Article Text |
id | pubmed-3693819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-36938192013-07-01 Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery Petersen, Latrisha K Huntimer, Lucas Walz, Katharine Ramer-Tait, Amanda Wannemuehler, Michael J Narasimhan, Balaji Int J Nanomedicine Original Research Several challenges are associated with current vaccine strategies, including repeated immunizations, poor patient compliance, and limited approved routes for delivery, which may hinder induction of protective immunity. Thus, there is a need for new vaccine adjuvants capable of multi-route administration and prolonged antigen release at the site of administration by providing a depot within tissue. In this work, we designed a combinatorial platform to investigate the in vivo distribution, depot effect, and localized persistence of polyanhydride nanoparticles as a function of nanoparticle chemistry and administration route. Our observations indicated that the route of administration differentially affected tissue residence times. All nanoparticles rapidly dispersed when delivered intranasally but provided a depot when administered parenterally. When amphiphilic and hydrophobic nanoparticles were administered intranasally, they persisted within lung tissue. These results provide insights into the chemistry- and route-dependent distribution and tissue-specific association of polyanhydride nanoparticle-based vaccine adjuvants. Dove Medical Press 2013 2013-06-18 /pmc/articles/PMC3693819/ /pubmed/23818778 http://dx.doi.org/10.2147/IJN.S45317 Text en © 2013 Petersen et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Petersen, Latrisha K Huntimer, Lucas Walz, Katharine Ramer-Tait, Amanda Wannemuehler, Michael J Narasimhan, Balaji Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery |
title | Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery |
title_full | Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery |
title_fullStr | Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery |
title_full_unstemmed | Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery |
title_short | Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery |
title_sort | combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693819/ https://www.ncbi.nlm.nih.gov/pubmed/23818778 http://dx.doi.org/10.2147/IJN.S45317 |
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