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Early Hippocampal Synaptic Loss Precedes Neuronal Loss and Associates with Early Behavioural Deficits in Three Distinct Strains of Prion Disease

Prion diseases are fatal neurodegenerative diseases of the CNS that are associated with the accumulation of misfolded cellular prion protein. There are several different strains of prion disease defined by different patterns of tissue vacuolation in the brain and disease time course, but features of...

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Detalles Bibliográficos
Autores principales:	Hilton, Kathryn J., Cunningham, Colm, Reynolds, Richard A., Perry, V. Hugh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694005/ https://www.ncbi.nlm.nih.gov/pubmed/23840812 http://dx.doi.org/10.1371/journal.pone.0068062

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