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Seroprevalence of Hepatitis E Virus Infection among Swine Farmers and the General Population in Rural Taiwan

OBJECTIVES: Hepatitis E virus (HEV) is an emerging pathogen. We evaluated the seroprevalence of HEV infection among swine farmers and the general population in Taiwan, a nonendemic country. METHODS: We conducted a cross-sectional seroepidemiologic study in rural Taiwan in 2012 and 2013. The study in...

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Autores principales: Lee, Jian-Te, Shao, Pei-Lan, Chang, Luan-Yin, Xia, Ning-Shao, Chen, Pei-Jer, Lu, Chun-Yi, Huang, Li-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694024/
https://www.ncbi.nlm.nih.gov/pubmed/23840620
http://dx.doi.org/10.1371/journal.pone.0067180
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author Lee, Jian-Te
Shao, Pei-Lan
Chang, Luan-Yin
Xia, Ning-Shao
Chen, Pei-Jer
Lu, Chun-Yi
Huang, Li-Min
author_facet Lee, Jian-Te
Shao, Pei-Lan
Chang, Luan-Yin
Xia, Ning-Shao
Chen, Pei-Jer
Lu, Chun-Yi
Huang, Li-Min
author_sort Lee, Jian-Te
collection PubMed
description OBJECTIVES: Hepatitis E virus (HEV) is an emerging pathogen. We evaluated the seroprevalence of HEV infection among swine farmers and the general population in Taiwan, a nonendemic country. METHODS: We conducted a cross-sectional seroepidemiologic study in rural Taiwan in 2012 and 2013. The study included swine farmers, health examination attendees, pregnant women, and students. A commercial enzyme-linked immunosorbent assay was used to detect immunoglobulin G (IgG) and IgM against HEV. Pertinent information was collected using a questionnaire. RESULTS: In total, 660 participants were enrolled in the study, including 156 swine farmers, 314 health examination attendees, 100 pregnant women, and 90 students. IgG anti-HEV was detected in 29.5% of swine farmers, 11.5% of health examination attendees, 2% of pregnant women, and 1.1% of students. Two subjects were positive for IgM anti-HEV. Logistic regression analysis revealed that swine farmers had an approximately 3.5-fold increased risk (odds ratio [OR], 3.46; 95% confidence interval [CI], 1.91–6.27; p<0.0001) for being seropositive for IgG anti-HEV as compared to the general population. Age was positively associated with seropositive rate (OR, 1.07 per year; 95% CI, 1.05–1.09; p<0.0001). CONCLUSION: HEV infection is prevalent in Taiwan. The seroprevalence of HEV infection is high in swine farmers and in the elderly population.
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spelling pubmed-36940242013-07-09 Seroprevalence of Hepatitis E Virus Infection among Swine Farmers and the General Population in Rural Taiwan Lee, Jian-Te Shao, Pei-Lan Chang, Luan-Yin Xia, Ning-Shao Chen, Pei-Jer Lu, Chun-Yi Huang, Li-Min PLoS One Research Article OBJECTIVES: Hepatitis E virus (HEV) is an emerging pathogen. We evaluated the seroprevalence of HEV infection among swine farmers and the general population in Taiwan, a nonendemic country. METHODS: We conducted a cross-sectional seroepidemiologic study in rural Taiwan in 2012 and 2013. The study included swine farmers, health examination attendees, pregnant women, and students. A commercial enzyme-linked immunosorbent assay was used to detect immunoglobulin G (IgG) and IgM against HEV. Pertinent information was collected using a questionnaire. RESULTS: In total, 660 participants were enrolled in the study, including 156 swine farmers, 314 health examination attendees, 100 pregnant women, and 90 students. IgG anti-HEV was detected in 29.5% of swine farmers, 11.5% of health examination attendees, 2% of pregnant women, and 1.1% of students. Two subjects were positive for IgM anti-HEV. Logistic regression analysis revealed that swine farmers had an approximately 3.5-fold increased risk (odds ratio [OR], 3.46; 95% confidence interval [CI], 1.91–6.27; p<0.0001) for being seropositive for IgG anti-HEV as compared to the general population. Age was positively associated with seropositive rate (OR, 1.07 per year; 95% CI, 1.05–1.09; p<0.0001). CONCLUSION: HEV infection is prevalent in Taiwan. The seroprevalence of HEV infection is high in swine farmers and in the elderly population. Public Library of Science 2013-06-26 /pmc/articles/PMC3694024/ /pubmed/23840620 http://dx.doi.org/10.1371/journal.pone.0067180 Text en © 2013 Lee et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lee, Jian-Te
Shao, Pei-Lan
Chang, Luan-Yin
Xia, Ning-Shao
Chen, Pei-Jer
Lu, Chun-Yi
Huang, Li-Min
Seroprevalence of Hepatitis E Virus Infection among Swine Farmers and the General Population in Rural Taiwan
title Seroprevalence of Hepatitis E Virus Infection among Swine Farmers and the General Population in Rural Taiwan
title_full Seroprevalence of Hepatitis E Virus Infection among Swine Farmers and the General Population in Rural Taiwan
title_fullStr Seroprevalence of Hepatitis E Virus Infection among Swine Farmers and the General Population in Rural Taiwan
title_full_unstemmed Seroprevalence of Hepatitis E Virus Infection among Swine Farmers and the General Population in Rural Taiwan
title_short Seroprevalence of Hepatitis E Virus Infection among Swine Farmers and the General Population in Rural Taiwan
title_sort seroprevalence of hepatitis e virus infection among swine farmers and the general population in rural taiwan
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694024/
https://www.ncbi.nlm.nih.gov/pubmed/23840620
http://dx.doi.org/10.1371/journal.pone.0067180
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