Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

Abnormal processing of TAR DNA binding protein 43 (TDP-43) has been identified as a major factor in neuronal degeneration during amyotrophic lateral sclerosis (ALS) or frontotemporal lobar degeneration (FTLD). It is unclear how changes to TDP-43, including nuclear to cytosolic translocation and subs...

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Detalles Bibliográficos
Autores principales: Moujalled, Diane, James, Janine L., Parker, Sarah J., Lidgerwood, Grace E., Duncan, Clare, Meyerowitz, Jodi, Nonaka, Takashi, Hasegawa, Masato, Kanninen, Katja M., Grubman, Alexandra, Liddell, Jeffrey R., Crouch, Peter J., White, Anthony R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694067/
https://www.ncbi.nlm.nih.gov/pubmed/23840699
http://dx.doi.org/10.1371/journal.pone.0067433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694067/
https://www.ncbi.nlm.nih.gov/pubmed/23840699
http://dx.doi.org/10.1371/journal.pone.0067433

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