Calpain-Mediated Processing of Adenylate Cyclase Toxin Generates a Cytosolic Soluble Catalytically Active N-Terminal Domain

Bordetella pertussis, the whooping cough pathogen, secretes several virulence factors among which adenylate cyclase toxin (ACT) is essential for establishment of the disease in the respiratory tract. ACT weakens host defenses by suppressing important bactericidal activities of the phagocytic cells....

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Detalles Bibliográficos
Autores principales: Uribe, Kepa B., Etxebarria, Aitor, Martín, César, Ostolaza, Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694075/
https://www.ncbi.nlm.nih.gov/pubmed/23840759
http://dx.doi.org/10.1371/journal.pone.0067648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694075/
https://www.ncbi.nlm.nih.gov/pubmed/23840759
http://dx.doi.org/10.1371/journal.pone.0067648

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