Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

Serine-threonine protein kinases are critical to CNS function, yet there is a dearth of highly selective, CNS-active kinase inhibitors for in vivo investigations. Further, prevailing assumptions raise concerns about whether single kinase inhibitors can show in vivo efficacy for CNS pathologies, and...

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Detalles Bibliográficos
Autores principales: Watterson, D. Martin, Grum-Tokars, Valerie L., Roy, Saktimayee M., Schavocky, James P., Bradaric, Brinda Desai, Bachstetter, Adam D., Xing, Bin, Dimayuga, Edgardo, Saeed, Faisal, Zhang, Hong, Staniszewski, Agnieszka, Pelletier, Jeffrey C., Minasov, George, Anderson, Wayne F., Arancio, Ottavio, Van Eldik, Linda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694096/
https://www.ncbi.nlm.nih.gov/pubmed/23840427
http://dx.doi.org/10.1371/journal.pone.0066226

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