Nontypeable Haemophilus Influenzae Infection Upregulates the NLRP3 Inflammasome and Leads to Caspase-1-Dependent Secretion of Interleukin-1β — A Possible Pathway of Exacerbations in COPD

RATIONALE: Nontypeable Haemophilus influenzae (NTHi) is the most common cause for bacterial exacerbations in chronic obstructive pulmonary disease (COPD). Recent investigations suggest the participation of the inflammasome in the pathomechanism of airway inflammation. The inflammasome is a cytosolic...

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Detalles Bibliográficos
Autores principales: Rotta detto Loria, Johannes, Rohmann, Kristina, Droemann, Daniel, Kujath, Peter, Rupp, Jan, Goldmann, Torsten, Dalhoff, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694113/
https://www.ncbi.nlm.nih.gov/pubmed/23840534
http://dx.doi.org/10.1371/journal.pone.0066818

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