Analysis of ultrastructural glomerular basement membrane lesions and podocytes associated with proteinuria and sclerosis in Osborne-Mendel rats with progressive glomerulonephropathy

The renal glomeruli of 12 male Osborne-Mendel (OM) rats 3 to 24 weeks old were examined by electron microscopy. Effacement of podocyte foot processes (FPs) developed at 3 weeks of age and became progressively worse over time. Loss or dislocation of the slit membrane was also found. Vacuoles and osmi...

Descripción completa

Detalles Bibliográficos
Autores principales: Yasuno, Kyohei, Kamiie, Junichi, Shirota, Kinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694195/
https://www.ncbi.nlm.nih.gov/pubmed/23814476
http://dx.doi.org/10.4142/jvs.2013.14.2.223
_version_ 1782274827605770240
author Yasuno, Kyohei
Kamiie, Junichi
Shirota, Kinji
author_facet Yasuno, Kyohei
Kamiie, Junichi
Shirota, Kinji
author_sort Yasuno, Kyohei
collection PubMed
description The renal glomeruli of 12 male Osborne-Mendel (OM) rats 3 to 24 weeks old were examined by electron microscopy. Effacement of podocyte foot processes (FPs) developed at 3 weeks of age and became progressively worse over time. Loss or dislocation of the slit membrane was also found. Vacuoles and osmiophilic lysosomes appeared in the podocytes starting at 6 weeks of age. Podocyte detachment from the glomerular basement membrane (GBM) was apparent at 18 weeks of age. Laminated GBM was occasionally observed in all animals. These features might lead to the development of spontaneous proteinuria and glomerulosclerosis in OM rats.
format Online
Article
Text
id pubmed-3694195
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher The Korean Society of Veterinary Science
record_format MEDLINE/PubMed
spelling pubmed-36941952013-06-28 Analysis of ultrastructural glomerular basement membrane lesions and podocytes associated with proteinuria and sclerosis in Osborne-Mendel rats with progressive glomerulonephropathy Yasuno, Kyohei Kamiie, Junichi Shirota, Kinji J Vet Sci Short Communication The renal glomeruli of 12 male Osborne-Mendel (OM) rats 3 to 24 weeks old were examined by electron microscopy. Effacement of podocyte foot processes (FPs) developed at 3 weeks of age and became progressively worse over time. Loss or dislocation of the slit membrane was also found. Vacuoles and osmiophilic lysosomes appeared in the podocytes starting at 6 weeks of age. Podocyte detachment from the glomerular basement membrane (GBM) was apparent at 18 weeks of age. Laminated GBM was occasionally observed in all animals. These features might lead to the development of spontaneous proteinuria and glomerulosclerosis in OM rats. The Korean Society of Veterinary Science 2013-06 2013-06-21 /pmc/articles/PMC3694195/ /pubmed/23814476 http://dx.doi.org/10.4142/jvs.2013.14.2.223 Text en © 2013 The Korean Society of Veterinary Science. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Yasuno, Kyohei
Kamiie, Junichi
Shirota, Kinji
Analysis of ultrastructural glomerular basement membrane lesions and podocytes associated with proteinuria and sclerosis in Osborne-Mendel rats with progressive glomerulonephropathy
title Analysis of ultrastructural glomerular basement membrane lesions and podocytes associated with proteinuria and sclerosis in Osborne-Mendel rats with progressive glomerulonephropathy
title_full Analysis of ultrastructural glomerular basement membrane lesions and podocytes associated with proteinuria and sclerosis in Osborne-Mendel rats with progressive glomerulonephropathy
title_fullStr Analysis of ultrastructural glomerular basement membrane lesions and podocytes associated with proteinuria and sclerosis in Osborne-Mendel rats with progressive glomerulonephropathy
title_full_unstemmed Analysis of ultrastructural glomerular basement membrane lesions and podocytes associated with proteinuria and sclerosis in Osborne-Mendel rats with progressive glomerulonephropathy
title_short Analysis of ultrastructural glomerular basement membrane lesions and podocytes associated with proteinuria and sclerosis in Osborne-Mendel rats with progressive glomerulonephropathy
title_sort analysis of ultrastructural glomerular basement membrane lesions and podocytes associated with proteinuria and sclerosis in osborne-mendel rats with progressive glomerulonephropathy
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694195/
https://www.ncbi.nlm.nih.gov/pubmed/23814476
http://dx.doi.org/10.4142/jvs.2013.14.2.223
work_keys_str_mv AT yasunokyohei analysisofultrastructuralglomerularbasementmembranelesionsandpodocytesassociatedwithproteinuriaandsclerosisinosbornemendelratswithprogressiveglomerulonephropathy
AT kamiiejunichi analysisofultrastructuralglomerularbasementmembranelesionsandpodocytesassociatedwithproteinuriaandsclerosisinosbornemendelratswithprogressiveglomerulonephropathy
AT shirotakinji analysisofultrastructuralglomerularbasementmembranelesionsandpodocytesassociatedwithproteinuriaandsclerosisinosbornemendelratswithprogressiveglomerulonephropathy

Ejemplares similares