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Cell-based approaches to joint surface repair: a research perspective
Repair of lesions of the articular cartilage lining the joints remains a major clinical challenge. Surgical interventions include osteochondral autograft transfer and microfracture. They can provide some relief of symptoms to patients, but generally fail to durably repair the cartilage. Autologous c...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
W.B. Saunders For The Osteoarthritis Research Society
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694304/ https://www.ncbi.nlm.nih.gov/pubmed/23598176 http://dx.doi.org/10.1016/j.joca.2013.04.008 |
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author | Roelofs, A.J. Rocke, J.P.J. De Bari, C. |
author_facet | Roelofs, A.J. Rocke, J.P.J. De Bari, C. |
author_sort | Roelofs, A.J. |
collection | PubMed |
description | Repair of lesions of the articular cartilage lining the joints remains a major clinical challenge. Surgical interventions include osteochondral autograft transfer and microfracture. They can provide some relief of symptoms to patients, but generally fail to durably repair the cartilage. Autologous chondrocyte implantation has thus far shown the most promise for the durable repair of cartilage, with long-term follow-up studies indicating improved structural and functional outcomes. However, disadvantages of this technique include the need for additional surgery, availability of sufficient chondrocytes for implantation, and maintenance of their phenotype during culture-expansion. Mesenchymal stem cells offer an attractive alternative cell-source for cartilage repair, due to their ease of isolation and amenability to ex vivo expansion while retaining stem cell properties. Preclinical and clinical studies have demonstrated the potential of mesenchymal stem cells to promote articular cartilage repair, but have also highlighted several key challenges. Most notably, the quality and durability of the repair tissue, its resistance to endochondral ossification, and its effective integration with the surrounding host tissue. In addition, challenges exist related to the heterogeneity of mesenchymal stem cell preparations and their quality-control, as well as optimising the delivery method. Finally, as our knowledge of the cellular and molecular mechanisms underlying articular cartilage repair increases, promising studies are emerging employing bioactive scaffolds or therapeutics that elicit an effective tissue repair response through activation and mobilisation of endogenous stem and progenitor cells. |
format | Online Article Text |
id | pubmed-3694304 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | W.B. Saunders For The Osteoarthritis Research Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-36943042013-07-01 Cell-based approaches to joint surface repair: a research perspective Roelofs, A.J. Rocke, J.P.J. De Bari, C. Osteoarthritis Cartilage Review Repair of lesions of the articular cartilage lining the joints remains a major clinical challenge. Surgical interventions include osteochondral autograft transfer and microfracture. They can provide some relief of symptoms to patients, but generally fail to durably repair the cartilage. Autologous chondrocyte implantation has thus far shown the most promise for the durable repair of cartilage, with long-term follow-up studies indicating improved structural and functional outcomes. However, disadvantages of this technique include the need for additional surgery, availability of sufficient chondrocytes for implantation, and maintenance of their phenotype during culture-expansion. Mesenchymal stem cells offer an attractive alternative cell-source for cartilage repair, due to their ease of isolation and amenability to ex vivo expansion while retaining stem cell properties. Preclinical and clinical studies have demonstrated the potential of mesenchymal stem cells to promote articular cartilage repair, but have also highlighted several key challenges. Most notably, the quality and durability of the repair tissue, its resistance to endochondral ossification, and its effective integration with the surrounding host tissue. In addition, challenges exist related to the heterogeneity of mesenchymal stem cell preparations and their quality-control, as well as optimising the delivery method. Finally, as our knowledge of the cellular and molecular mechanisms underlying articular cartilage repair increases, promising studies are emerging employing bioactive scaffolds or therapeutics that elicit an effective tissue repair response through activation and mobilisation of endogenous stem and progenitor cells. W.B. Saunders For The Osteoarthritis Research Society 2013-07 /pmc/articles/PMC3694304/ /pubmed/23598176 http://dx.doi.org/10.1016/j.joca.2013.04.008 Text en © 2013 Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Review Roelofs, A.J. Rocke, J.P.J. De Bari, C. Cell-based approaches to joint surface repair: a research perspective |
title | Cell-based approaches to joint surface repair: a research perspective |
title_full | Cell-based approaches to joint surface repair: a research perspective |
title_fullStr | Cell-based approaches to joint surface repair: a research perspective |
title_full_unstemmed | Cell-based approaches to joint surface repair: a research perspective |
title_short | Cell-based approaches to joint surface repair: a research perspective |
title_sort | cell-based approaches to joint surface repair: a research perspective |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694304/ https://www.ncbi.nlm.nih.gov/pubmed/23598176 http://dx.doi.org/10.1016/j.joca.2013.04.008 |
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