Comparison between the Repression Potency of siRNA Targeting the Coding Region and the 3′-Untranslated Region of mRNA

Small interfering RNAs (siRNAs) are applied for post-transcriptional gene silencing by binding target mRNA. A target coding region is usually chosen, although the 3′-untranslated region (3′-UTR) can also be a target. This study elucidates whether the coding region or 3′-UTR elicits higher repression...

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Detalles Bibliográficos
Autores principales: Lai, Ching-Fang, Chen, Chih-Ying, Au, Lo-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694366/
https://www.ncbi.nlm.nih.gov/pubmed/23841081
http://dx.doi.org/10.1155/2013/637850

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